to provide information about the known and explored therapeutic
protein and nucleic acid targets, the targeted disease, pathway
information and the corresponding drugs directed at each of these
targets. Also included in this database are links to relevant
databases containing information about target function, sequence,
3D structure, ligand binding properties, enzyme nomenclature and
drug structure, therapeutic class, clinical development status.
All information provided are fully referenced.
This database currently contains 2,589
targets (including 397 successful, 723 clinical trial,
and 1,469 research targets), and 31,614
drugs (including 2,071
approved, 9,528 clinical
trial, 17,803 experimental
drugs). 20,278 small molecules and 653
antisense drugs are with available structure or oligonucleotide sequence.
The database incorporates the ICD-10-CM and ICD-9-CM codes of the International Classification of Diseases (covering 2,537 disease conditions, 2,163 targets, and 14,108 drugs), and the pathway classification system of KEGG, MetaCyc/BioCyc, NetPath, PANTHER pathway, PathWhiz, PID, Reactome, and WikiPathways pathway (covering 302 KEGG, 211 MetaCyc/BioCyc, 26 NetPath, 134 PANTHER pathway, 99 PathWhiz, 222 PID, 578 Reactome, and 524 WikiPathways pathway entries, 1,428 targets and 19,903 drugs). Moreover, this database contains biomarkers (1,755 biomarkers for 365 disease conditions), drug scaffolds (210 scaffolds for 714 drugs and leads), 1,008 nature-derived agents, 20,818 multi-target agents against 385 target-pairs, and the activity data of 1,436 agents against 297 cell-lines.