Therapeutic Targets Database
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TTD Drug ID: DAP000004

Drug Information
NameDasatinib
Synonyms302962-49-8; LS-186641; MolPort-003-846-143; EC-000.2122; LS-187773; BCB03_000715; CHEBI:49375; 1N1; UNII-X78UG0A0RN; BMS-354825, Sprycel, BMS354825, Dasatinib; 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide; SPRYCEL (TN); nchembio.117-comp11; Sprycel; Dasatinib anhydrous; S1021_Selleck; NSC-732517; CHEMBL1421; LS-187028; N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE; N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; FT-0084503; Dasatinib (USAN); CID3062316; N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide; Kinome_3650; I14-1972; BMS354825; dasatinibum; 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-; AC1MI3ET; BMS 354825; N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide; AC1Q2P0C; D03658; Dasatinib, BMS 354825; EN002710; C488369; nchembio.162-comp4; 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-; (18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide; DB01254; N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, monohydrate; Spyrcel; NCGC00181129-01; Dasatinib; BMS-354825; AmbotzLS-1203; nchembio.332-comp1; NSC732517; Dasatinib [USAN]
Trade NameSprycel
CompanyBristol Myers Squibb
IndicationChronic myelogenous leukemia
[ICD9: 205.1   ICD10: C92.1]
Launched    [1]
Solid tumours, multiple myeloma
[ICD9: 140-199, 203.0, 210-229   ICD10: C00-C75, C7A, C7B, C90.0, D10-D36, D3A]
Phase II    [1]
Structure

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InChI1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-
17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13
,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChIKeyZBNZXTGUTAYRHI-UHFFFAOYSA-N
Canonical SMILESCC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 302962-49-8
FormulaC22H26ClN7O2S
PubChem Compound IDCID 3062316.
PubChem Substance IDSID 3865636.
ChEBI49375;
SuperDrug ATC IDL01XE06
L01XE06
TargetProto-oncogene tyrosine-protein kinase ABL1Inhibitor[2][3][4]
Proto-oncogene tyrosine-protein kinase ABL1Multitarget[2][3][4]
Proto-oncogene tyrosine-protein kinase FynInhibitor[2][3][4]
Proto-oncogene tyrosine-protein kinase FynMultitarget[2][3][4]
Proto-oncogene tyrosine-protein kinase LCKInhibitor[2][3][4]
Proto-oncogene tyrosine-protein kinase LCKMultitarget[2][3][4]
Proto-oncogene tyrosine-protein kinase SRCInhibitor[2][3][4]
Proto-oncogene tyrosine-protein kinase SRCMultitarget[2][3][4]
Ref 1Current and future treatments of bone metastases. Expert Opin Emerg Drugs. 2008 Dec;13(4):609-27. To Reference
Ref 2A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference
Ref 3In vitro and clinical investigation of the relationship between CCR5 receptor occupancy and anti-HIV activity of Aplaviroc. J Clin Pharmacol. 2008 Oct;48(10):1179-88. Epub 2008 Aug 1. To Reference
Ref 4Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today. 2007 Jan;12(1-2):34-42. Epub 2006 Nov 28. To Reference



 

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