Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DAP000005

Drug Information
NameSunitinib
SynonymsPDGF TK antagonist; 1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-; AC1NS62J; SU 11248; 5-(5-FLUORO-2-OXO-1,2-DIHYDRO-INDOL-3-YLIDENEMETHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID (2-DIETHYLAMINO-ETHYL)-AMIDE; NSC736511; SU-11248J; 326914-13-0; NSC750690; K00588a; Su-011248; Sunitinib; SU-12662; KS-5022; CHEMBL535; UNII-V99T50803M; Sunitanib; 557795-19-4; N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; NCGC00164631-01; SU11248; 1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)- (5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-; LS-187023; DB01268; I01-1229; CID5329102; SU-11248; CHEBI:38940; sunitinibum; DB07417; LS-187648; N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; FT-0083556; Sutent; D08552; Sunitinib (free base); Sunitinib (INN); EN002687; 1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
Trade NameSutent
CompanyPfizer (Sugen)
IndicationAdvanced renal cell carcinoma
[ICD9: 189   ICD10: C64]
Launched    [1]
Advanced renal cell carcinoma
[ICD9: 189   ICD10: C64]
Phase II    [1]
Structure

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Click to save drug structure in 2D MOL format
InChI1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12
-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1
-4H3,(H,24,29)(H,26,28)/b17-12-
InChIKeyWINHZLLDWRZWRT-ATVHPVEESA-N
Canonical SMILESCCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C    
Isomeric SMILESCCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 557795-19-4
FormulaC22H27FN4O2
PubChem Compound IDCID 5329102.
PubChem Substance IDSID 3889616.
ChEBI38940;
SuperDrug ATC IDL01XE04
L01XE04
TargetFL cytokine receptorInhibitor[2][3][4][5]
FL cytokine receptorMultitarget[2][3][4][5]
Mast/stem cell growth factor receptorInhibitor[2][3][4][5]
Mast/stem cell growth factor receptorMultitarget[2][3][4][5]
Platelet-derived growth factor receptorInhibitor[2][3][4][5]
Platelet-derived growth factor receptorMultitarget[2][3][4][5]
Vascular endothelial growth factor receptor 2Inhibitor[2][3][4][5]
Vascular endothelial growth factor receptor 2Multitarget[2][3][4][5]
Ref 1Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. To Reference
Ref 2FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML. Drug Resist Updat. 2009 Jun;12(3):81-9. Epub 2009 May 20. To Reference
Ref 3FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro. Cancer Res. 2009 Apr 1;69(7):3032-41. Epub 2009 Mar 24. To Reference
Ref 4A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference
Ref 5Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today. 2007 Jan;12(1-2):34-42. Epub 2006 Nov 28. To Reference



 

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