Therapeutic Targets Database
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TTD Drug ID: DAP000006

Drug Information
NameSorafenib
SynonymsBAY-54-9085; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; BAY-43-0006; Sorafenib [INN]; NCGC00167488-01; CID216239; D08524; CHEBI:50924; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Kinome_766; Bio-0100; sorafenibum; BAY 439006; Sorafenib; AC-1674; BAY 54-9085 (tosylate salt); LS-187788; DB00398; ZINC01493878; 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-; LS-186067; MolPort-003-850-270; Nexavar; DB07438; BAY-43-9006; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; NSC-724772; K00597a; AB1004622; BRD-K23984367-001-01-8; STK627350; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; I06-0856; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; BAY 43-9006 (free base); CHEBI:47228; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; nchembio.117-comp17; CHEMBL1336; N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; BAX; EN002709; AC1L50CF; Sorafenib (INN); 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-; NSC747971; LS-187021; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; UNII-9ZOQ3TZI87; BAY 43-9006; BAY43-9006; 284461-73-0; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
Trade NameNexavar
CompanyBayer AG/Onyx Pharmaceuticals
IndicationAdvanced renal cell carcinoma
[ICD9: 189   ICD10: C64]
Launched    [1]
Hepatocellular carcinoma, NSCLC, melanoma
[ICD9: 155, 162, 172   ICD10: C22.0, C33, C34, C43]
Phase III    [1]
Myelodyspalstic syndrome, AML, head & neck cancer, breast, colon, ovarian, pancreatic cancer
[ICD9: 140-149, 140-229, 157, 183, 205.0   ICD10: C00-C96, C07-C14, C25, C32, C33, C56, C92.0]
Phase II    [1]
Structure

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InChI1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6
-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,2
6,30)(H2,28,29,31)
InChIKeyMLDQJTXFUGDVEO-UHFFFAOYSA-N
Canonical SMILESCNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 284461-73-0
FormulaC21H16ClF3N4O3
PubChem Compound IDCID 216239.
PubChem Substance IDSID 789424.
ChEBI50924;
SuperDrug ATC IDL01XE05
L01XE05
TargetB-Raf proto-oncogene serine/threonine-protein kinaseInhibitor[2][3][4]
B-Raf proto-oncogene serine/threonine-protein kinaseMultitarget[2][3][4]
Proto-oncogene tyrosine-protein kinase receptor retInhibitor[2][3][4]
Proto-oncogene tyrosine-protein kinase receptor retMultitarget[2][3][4]
Vascular endothelial growth factor receptorInhibitor[2][3][4]
Vascular endothelial growth factor receptorMultitarget[2][3][4]
Ref 1Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. To Reference
Ref 2A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference
Ref 3Pituitary tumors. Curr Treat Options Neurol. 2009 Jul;11(4):287-96. To Reference
Ref 4Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today. 2007 Jan;12(1-2):34-42. Epub 2006 Nov 28. To Reference



 

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