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TTD Drug ID: DAP000033

Drug Information
NameMitotane
SynonymsChloditan; 1,1-Dichloro-2,2-bis(2,4'-dichlorophenyl)ethane; KBio2_007641; NCI-C04933; 49015_SUPELCO; Mitotan; o,p-Tde; 2-(o-Chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloroethane; NCGC00015226-09; 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane; UNII-78E4J5IB5J; NCGC00091374-02; Lopac0_000251; CID4211; Mitotanum [INN-Latin]; ST51016017; AI3-07575; NCGC00091374-01; Spectrum2_000916; 2,4'-Ddd; 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane; 53-19-0; NCGC00091374-05; Benzene, 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-; HMS502D05; MLS001335900; Ethane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)- (8CI); KBioGR_001237; NCGC00015226-03; MLS002152914; mitotane; ortho,para DDD; Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-; DB00648; 25925_SIGMA; HMS1923K19; 1-Chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)benzene; C14H10Cl4; C 3010; NCGC00091374-06; 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene; SPBio_000792; Mitotane (JAN/USP/INN); KBioSS_002513; MLS002153233; CB 313; Mytotan; WLN: GYGYR BG&R DG; Chlodithane; NINDS_000703; 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane; SMR000326696; AC1L1HNV; 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; (+-)-1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; Lysodren; Khlodithan; HMS2091E07; 35485_RIEDEL; Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)-, (+-)-; Lysodren (TN); D008939; BRN 2056007; CHEMBL1670; CB-313; o,p'-DDD; D00420; NCGC00091374-04; NCI60_003688; EU-0100251; DivK1c_000703; KBio2_005073; Chlodithan; BSPBio_002517; HSDB 3240; PS694_SUPELCO; NSC38721; o,p-DDD; IDI1_000703; Mitotanum; 35485_FLUKA; o,p'-Dichlorodiphenyldichloroethane; Mitotano; EINECS 200-166-6; Spectrum_001959; AC1Q3H13; Bristol Myers Squibb Brand of Mitotane; 2,4'-Dichlorodiphenyldichloroethane; Mitotane [USAN:INN:JAN]; Mitotano [INN-Spanish]; Spectrum4_000709; 1,1-Dichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl)ethane; Prestwick_75; CB313; MolPort-001-779-578; Khloditan; NCGC00091374-03; (2,4'-Dichlorodiphenyl)dichloroethane; CCRIS 4397; Spectrum3_000869; Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)-; (o,p)-DDD; NSC-38721; 2,4'-Dichlorophenyldichlorethane; MLS001335899; ortho,para-DDD; KBio3_002017; o,p'-TDE; LS-185; Bristol-Myers Squibb Brand of Mitotane; KBio1_000703; KBio2_002505; Spectrum5_002060; SPECTRUM330082; Ethane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-; 25925_FLUKA; DDD, o,p'-; NSC 38721
Trade NameLysodren
CompanyBristol Myers Squibb
IndicationAdrenocortical carcinoma
[ICD9: 194   ICD10: C74.0]
Approved    [1]
Structure

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InChI1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/
h1-8,13-14H
InChIKeyJWBOIMRXGHLCPP-UHFFFAOYSA-N
Canonical SMILESC1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 53-19-0
FormulaC14H10Cl4
PubChem Compound IDCID 4211.
PubChem Substance IDSID 94579.
SuperDrug ATC IDL01XX23
SuperDrug CAS ID000053190;
TargetEstrogen receptor alphaBinder[2][3]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016885 To Reference
Ref 2Mitotane for adrenocortical carcinoma treatment. Curr Opin Investig Drugs. 2005 Apr;6(4):386-94. To Reference
Ref 3Mitotane has an estrogenic effect on sex hormone-binding globulin and corticosteroid-binding globulin in humans. J Clin Endocrinol Metab. 2006 Jun;91(6):2165-70. Epub 2006 Mar 21. To Reference



 

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