Therapeutic Targets Database
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TTD Drug ID: DAP000035

Drug Information
NameTrichlormethiazide
SynonymsKBio3_002146; Trichlormethiazidum; BPBio1_000825; Naquasone; Isestran; Spectrum_000520; Jones Brand of Trichloromethiazide; trichloromethiazide, 6; Flurese; BSPBio_000749; D014237; KBio1_000366; LS-40435; 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide; Prestwick0_000825; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide; HMS2092O19; 6-Chloro-3-[dichloromethyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-,1,1-dioxide; Spectrum3_001373; MLS000028705; DivK1c_000366; Triclormetiazide; KBio2_006136; Prestwick_1020; NSC 61560; Kubacron; AR-1H7280; CID5560; EINECS 205-118-8; Trichlormetazid; HMS1570F11; 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; Naqua (TN); C07767; T1318; Diurese; 3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; Trichlorex; Triclormetiazide [DCIT]; 3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide; Schering Brand of Trichlormethiazide; Carvacron; Trichlormethiazide [INN:JAN]; Aquazide; Trichlormethiazidum [INN-Latin]; Metahydrin; Metatensin; Nakva; SPBio_000916; Triclormetiazida; 6-Chloro-3-dichloromethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide; NINDS_000366; HMS1921G13; UNII-Q58C92TUN0; Anistadin; Triflumen; KBioGR_000833; MLS001076545; BSPBio_002926; HMS501C08; Fluitran; Prestwick3_000825; AC1L1KMB; BRD-A28940325-001-05-9; IDI1_000366; Eurinol; Triclormetiazide [Italian]; Spectrum2_000948; Trichloromethiadiazide; 133-67-5; SPECTRUM1500590; Trichlormethiazid; Esmarin; Diuroral; Diurazida; SMR000058712; Trichlormethiazide (JP15/USP/INN); NSC61560; HMS2090G08; Tolcasone; 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Trichlordiuride; 6-Chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide; Aponorin; NCGC00089756-02; NCGC00089756-03; Intromene; WLN: T66 BSWM EM DHJ DYGG HG ISZW; 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; Flutra; Diu-Hydrin; KBio2_003568; Trichlormas; CHEMBL1054; Ciba 7057-Su; HSDB 3406; Salurin (wadel); 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide, (+-)-; T1016_SIGMA; Flurese (VAN); SPBio_002670; Triclordiuride; Achletin; Naqua; Chlopolidine; trichlormethiazide; Schebitran; Triclormetiazida [INN-Spanish]; D00658; Prestwick1_000825; 3-Dichloromethylhydrochlorothiazide; Tachionin; KBio2_001000; Spectrum5_001074; MolPort-003-666-298; Trichlormethiazide W/ Reserpine; Trichloromethiazide; Gangesol; (+-)-6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide; AB00052117; Hydrotrichlorothiazide; Prestwick2_000825; 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide; KBioSS_001000; NCIOpen2_007750; DB01021; Cretonin; American Urologicals Brand of Trichloromethiazide; ST51015129; Spectrum4_000367; 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide; AC1Q6TQ0; BRN 0629145
Trade NameAchletin; Diu-Hydrin; Triflumen
CompanyHoechst Marion Roussel
IndicationOedema and hypertension
[ICD9: 401, 782.3   ICD10: I10, I11, I12, I13, I15, R60.9]
Approved    [1]
Structure

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InChI1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)
7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
InChIKeyLMJSLTNSBFUCMU-UHFFFAOYSA-N
Canonical SMILESC1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)NC(N2)C(Cl)Cl    
Therapeutic ClassAntihypertensive Agents
CAS NumberCAS 133-67-5
FormulaC8H8Cl3N3O4S2
PubChem Compound IDCID 5560.
PubChem Substance IDSID 9969.
SuperDrug ATC IDC03AA06
SuperDrug CAS ID000133675;
TargetNa+/K+/2CL-co-transporterBlocker[2]
Ref 1Current usage of diuretics among hypertensive patients in Japan: the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study. Hypertens Res. 2006 Nov;29(11):857-63. To Reference
Ref 2Function and regulation of epithelial sodium transporters in the kidney of a salt-sensitive hypertensive rat model. J Hypertens. 2007 May;25(5):1065-72. To Reference



 

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