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TTD Drug ID: DAP000057

Drug Information
NameMitoxantrone
Synonyms9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-; KBio3_002660; Mitoxanthrone; Misostol (TN); KBioGR_001531; 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl] amino]-; 70711-41-0 (acetate); SPBio_000756; BSPBio_000569; Dihydroxyanthraquinone; Spectrum4_000866; Mitoxantrone [INN]; 70945-62-9; Mitoxantrona; 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-; 70476-82-3; NSC-279836; NSC-301739; Spectrum_001655; 1,4-Dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione; BRD-K21680192-300-05-2; S2485_Selleck; 1,4-Bis(2-(2-hydroxyethylamino)ethyl)amino)-5,8-dihydroxyanthraquinone; MLS002703044; 70476-82-3 (hydrochloride); NCGC00015693-02; UNII-BZ114NVM5P; Mitoxantron; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione; DivK1c_000516; Lopac-M-6545; Mitoxantronum [INN-Latin]; Mitoxantrone (free base); 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE; LS-20638; CAS-70476-82-3; ANTHRAQUINONE, 5,8-BIS((2-((2-HYDROXYETHYL)AMINO)ETHYL)AMINO)-1,4-DIHYDROXY-; Prestwick0_000385; C11195; Spectrum5_001205; NSC301739; Misostol; BIDD:PXR0181; KBio2_007271; SR-01000076001; VU0244399-2; SPBio_002490; DHAQ; MITOXANTRONE, Mitoxantrone Hydrochloride, Mitoxantrone dihydrochloride, MITOXANTHRONE HYDROCHLORIDE; NINDS_000516; CCRIS 7604; KBio1_000516; KBioSS_002135; NSC299195; NSC-299195; 70711-41-0; BPBio1_000627; NCI60_002276; IDI1_000516; HMS2090D05; SMR001549953; 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon; NSC-287836; Prestwick3_000385; CHEMBL58; AB00053716; NCGC00162251-01; AN-584/42007670; Spectrum2_000908; Mitozantrone; AC1L1HNY; MITOXANTRONE, 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)ANTHRA-9,10-QUINONE; DHAQ HCl; Prestwick2_000385; DHAD; Liposome Encapsulated Mitoxantrone (LEM); Mitoxantrona [INN-Spanish]; 1,4-Dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedione; Mitoxantrone (INN); NSC 279836; KBio2_002135; Lopac0_000779; DB01204; SR-01000076001-7; 2fum; 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthra-9,10-quinone; D08224; 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione; Mitozantrone hydrochloride; BRN 2795126; NCI60_002535; NCGC00015693-04; CID4212; NSC279836; Prestwick1_000385; 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)- (9CI); MIX; MolPort-003-849-239; 65271-80-9; 5,8-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxyanthraquinone; KBio2_004703; Novantrone(R) (mitoxantrone for injection concentrate); CHEBI:50729; 137635-96-2; STK631833; Spectrum3_001590; DHAQ (*Diacetate salt*); mitoxantrone; NChemBio.2007.10-comp17; SMP2_000179; Mitoxantrone 2HCl; Neuro_000153; BRD-K21680192-300-07-8; NSC-301739D; BSPBio_003160; NCGC00015693-01; C22H28N4O6; Mitoxantronum
Trade NameNovantrone
CompanySerono, Inc
IndicationCancers
[ICD9: 140-229   ICD10: C00-C96]
Approved    [1]
Structure

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InChI1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-
17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2
InChIKeyKKZJGLLVHKMTCM-UHFFFAOYSA-N
Canonical SMILESC1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO    
Therapeutic ClassAnalgesics
CAS NumberCAS 65271-80-9
FormulaC22H28N4O6
PubChem Compound IDCID 4212.
PubChem Substance IDSID 13376.
ChEBI50729;
SuperDrug ATC IDL01DB07
SuperDrug CAS ID065271809;
TargetDNA topoisomerase IIInhibitor[1]
Ref 1Acute promyelocytic leukemic involvement of the optic nerves following mitoxantrone treatment for multiple sclerosis. J Neurol Sci. 2008 Oct 15;273(1-2):144-7. Epub 2008 Aug 6. To Reference



 

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