Therapeutic Targets Database
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TTD Drug ID: DAP000064

Drug Information
NameLofexidine
SynonymsAC1L1K1D; DB04948; Lofexidinum; CHEMBL17860; Lofexidinum [INN-Latin]; CID30668; Britlofex; 2-Imidazoline 2-(1-(2,6-dichlorophenoxy)ethyl)-; Lofexidine [INN:BAN]; CHEBI:51368; D08141; AC1Q3Q8L; 1H-Imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-; 2-(a-(2,6-dichlorophenoxy)ethyl)2-imidazoline; Lofexidina; 1H-Imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro- (9CI); Lofexidine; 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole; MolPort-003-848-405; 2-(alpha-(2,6-dichlorophenoxy)ethyl) delta-2-imidazoline; 21498-08-8 (mono-hydrochloride); 31036-80-3; 2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole; HMS2090C03; 2-{1-[(2,6-dichlorophenyl)oxy]ethyl}-4,5-dihydro-1H-imidazole; LS-79612; 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline; Lofexidina [INN-Spanish]; C11H12Cl2N2O; Lofexidine (INN)
Trade NameBritlofex
CompanyBritannia Pharmacuetical
IndicationHeroin and opiate withdrawal
[ICD9: 304   ICD10: F10-F19]
Approved    [1]
Structure

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InChI1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-
4,7H,5-6H2,1H3,(H,14,15)
InChIKeyKSMAGQUYOIHWFS-UHFFFAOYSA-N
Canonical SMILESCC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl    
Therapeutic ClassAntihypertensive Agents
CAS NumberCAS 31036-80-3
FormulaC11H12Cl2N2O
PubChem Compound IDCID 30668.
PubChem Substance IDSID 207368.
ChEBI51368;
SuperDrug ATC IDN07BC04
SuperDrug CAS ID031036803;
TargetAlpha-2 adrenergic receptorAgonist[2][1]
Ref 1A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal. Drug Alcohol Depend. 2008 Sep 1;97(1-2):158-68. Epub 2008 May 27. To Reference
Ref 2Clinical pharmacokinetics of lofexidine, the alpha 2-adrenergic receptor agonist, in opiate addicts plasma using a highly sensitive liquid chromatography tandem mass spectrometric analysis. Am J Drug Alcohol Abuse. 2008;34(5):611-6. To Reference



 

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