Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DAP000070

Drug Information
SynonymsLS-187367; I06-1429; Ramelteon (JAN/USAN/INN); Ramelteon; DB00980; Ramelteon [USAN]; D02689; CHEMBL1218; (-)-N-(2-(((8S)-1,6,7,8-Tetrahydro-2H-indeno(5,4-b)furan-8-yl)ethyl)propanamide; CID208902; (S)-N-(2-(1,6,7,8-tetrahydro-2H-indeno-(5,4)furan-8-yl)ethyl)propionamide; Rozerem, TAK-375, Ramelteon; S1259_Selleck; UNII-901AS54I69; AC-5275; C495910; AC1Q5OQL; AR-1K4568; HMS1922H18; n-{2-[(8s)-1,6,7,8-tetrahydro-2h-indeno[5,4-b]fur-8-yl]ethyl}propanamid; 196597-26-9; LS-186569; TAK-375; CHEBI:321962; BRD-K28761891-001-01-0; AC1L4LKM; SPECTRUM1505817; Propanamide, N-(2-((8S)-1,6,7,8-tetrahydro-2H-indeno(5,4-b)furan-8-yl)ethyl)-; Rozerem; HMS2093F12; BSPBio_002318; MolPort-003-666-751; ZINC03960338; Rozerem (TN); N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide
Trade NameRozerem
IndicationCircadian rhythm sleep disorder(CRSD)
[ICD9: 327.3, 780.55   ICD10: G47.2]
Discontinued    [1]
[ICD9: 307.41, 307.42, 327.0, 780.51, 780.52   ICD10: F51.0, G47.0]
Approved    [1]

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Canonical SMILESCCC(=O)NCCC1CCC2=C1C3=C(C=C2)OCC3    
Therapeutic ClassHypnotics and Sedatives
CAS NumberCAS 196597-26-9
PubChem Compound IDCID 208902.
PubChem Substance IDSID 783731.
SuperDrug ATC IDN05CH02
TargetMelatonin receptor type 1AAgonist[2]
Melatonin receptor type 1AAgonist[3]
Melatonin receptor type 1AMultitarget[2]
Melatonin receptor type 1AMultitarget[3]
Melatonin receptor type 1BAgonist[2]
Melatonin receptor type 1BAgonist[4]
Melatonin receptor type 1BMultitarget[2]
Melatonin receptor type 1BMultitarget[4]
Ref 1Emerging therapies for fibromyalgia. Expert Opin Emerg Drugs. 2008 Mar;13(1):53-62. To Reference
Ref 2Takeda. Product Development Pipeline. July 31 2009. To Reference
Ref 3Ramelteon: a review of its therapeutic potential in sleep disorders. Adv Ther. 2009 Jun;26(6):613-26. Epub 2009 Jun 30. To Reference
Ref 4Effects of ramelteon 8 mg on objective sleep latency in adults with chronic insomnia on nights 1 and 2: pooled analysis. Curr Med Res Opin. 2009 May;25(5):1209-13. To Reference


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