Therapeutic Targets Database
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TTD Drug ID: DAP000098

Drug Information
NameConivaptan
Synonyms4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide; Conivaptan; L001531; N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide; MolPort-005-940-873; UNII-0NJ98Y462X; AC1L45SX; YM 087; ZINC12503187; PDSP2_001718; L001073; N-[4-(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide; Conivaptan [INN]; D07748; PDSP1_001735; Conivaptan (INN); (1,1'-Biphenyl)-2-carboxamide, N-(4-(4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)phenyl)-; CID151171; LS-187117; 210101-16-9; I14-8805; YM-087; CHEMBL1755; YM087; DB00872; CHEBI:681850
Trade NameVaprisol
CompanyAstellas Pharma Inc
IndicationEuvolemic hyponatremia
[ICD9: 276.1   ICD10: E87.1]
Approved    [1]
Structure

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InChI1S/C32H26N4O2/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21
)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-
4-10-22/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37)
InChIKeyIKENVDNFQMCRTR-UHFFFAOYSA-N
Canonical SMILESCC1=NC2=C(N1)CCN(C3=CC=CC=C32)C(=O)C4=CC=C(C=C4)NC(=O)C5=CC=CC=C5C6=CC=
CC=C6    
Therapeutic ClassAquaresis promoters
CAS NumberCAS 210101-16-9
FormulaC32H26N4O2
PubChem Compound IDCID 151171.
PubChem Substance IDSID 728713.
SuperDrug ATC IDC03XA02
C03XA02
TargetVasopressin V1a receptorAntagonist[2][3]
Vasopressin V1a receptorMultitarget[2][3]
Vasopressin V2 receptorAntagonist[2][3]
Vasopressin V2 receptorMultitarget[2][3]
Ref 1Emerging diuretics for the treatment of heart failure. Expert Opin Emerg Drugs. 2009 Mar;14(1):195-204. To Reference
Ref 2Conivaptan: promise of treatment in heart failure. Expert Opin Pharmacother. 2009 Sep;10(13):2161-9. To Reference
Ref 3Conivaptan: a step forward in the treatment of hyponatremia? Ther Clin Risk Manag. 2008 Apr;4(2):315-26. To Reference



 

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