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TTD Drug ID: DAP000101

Drug Information
NameLoratadine
SynonymsI14-0747; Lorastine; Talorat Dy; Lorfast; 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester; D00364; L 9664; NCGC00023125-06; Alavert, Claritin, Loratadine; DivK1c_000792; Loratyne; Loranox; EU-0100680; Loraver; Allertidin; Sch 29851; Sch29851; NCGC00023125-05; Loracert; D017336; Lergy; Tadine; Sinhistan Dy; HMS502H14; Loratadinum [Latin]; ZINC00537931; 1-Piperidenecarboxylic acid, 4-(8-chloro-5,6-duhydro-11H-benzo [5,6]cyclohepta[1,2-b]-pyridin-11-ylidene)-, ethyl ester; KBio1_000792; 1-piperidinecarboxylic acid,4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-,ethyl ester; Restamine; NINDS_000792; NCGC00015619-10; Spectrum2_001584; BIDD:GT0198; Spectrum5_001650; Claritin D; C22H23ClN2O2; Loradex; Lowadina; Bonalerg; Oprea1_027965; Sanelor; Lopac-L-9664; Loratadine [USAN:BAN:INN]; KBio2_004544; Loratadina; Clarinase; KBio2_007112; Claritin reditab; Anhissen; LS-114660; AC-2086; Claratyne; Pylor; NCGC00023125-04; Lopac0_000680; HSDB 3578; SAM001246987; BRD-K82795137-001-02-3; BSPBio_002300; Optimin; MLS000069647; HMS2090O18; Claritin Hives Relief Reditab; Zeos; Tocris-1944; Clarityne-D; 79794-75-5; BRD-K82795137-001-10-6; STK574925; Clarinase Reperabs; NSC721075; Civeran; NCGC00023125-02; Claritin Reditabs; KBio2_001976; Loratadine (JAN/USAN/INN); L0223; IDI1_000792; Histaloran; CPD000058255; Fristamin; KBio3_001520; Loratidine; HMS2051G11; NCGC00015619-06; Claritine; Rinomex; Loratadine Wyeth Brand; Loratadinum; Lisino; Versal; loratadine; 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester; Claritin (TN); SMR000058255; Sensibit; Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate; CID3957; ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate; L9664_SIGMA; 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester; Lorantis; Clarityne; Alerpriv; Spectrum3_000740; Spectrum4_000177; NCI60_041473; Clarityn; Sch-29851; Alavert; Sohotin; Biloina; KBioSS_001976; Alarin; DB00455; Nularef; Roletra; Spectrum_001496; BB_SC-2109; Rhinase; NCGC00023125-07; KBioGR_000693; NCGC00015619-02; TL8005389; HMS2093I15; Bedix Loratadina; Clarium; Aerotina; Lertamine; Children's Claritin; MolPort-002-507-846; AC1L1H3E; Loritine; Claratyne Cold; Velodan; Wyeth Brand of Loratadine; S1358_Selleck; Loratadina [Spanish]; MLS000758260; Claritin Hives Relief; Polaratyne; 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester; Loratadine Redidose; Loradif; NCGC00015619-01; MLS001148466; SPBio_001548; Lesidas; Claritin; Claratyne Decongestant; CHEMBL998; SPECTRUM1503712; UNII-7AJO3BO7QN; L000667; 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester; Clarityne Dy Repetabs
Trade NameClaritin; Claritin-D; Claritine; Clarityn; Clarityne; Fristamin; Lorfast; Lomilan; Flonidan; Symphoral; Roletra; Rinolan; AllergyX; Alavert; Tidilor
CompanySchering-Plough Corporation
IndicationAllergies
[ICD9: 995.3   ICD10: T78.4]
Approved    [1]
Structure

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InChI1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23
)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12
-13H2,1H3
InChIKeyJCCNYMKQOSZNPW-UHFFFAOYSA-N
Canonical SMILESCCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1    
Therapeutic ClassAntihistamines
CAS NumberCAS 79794-75-5
FormulaC22H23ClN2O2
PubChem Compound IDCID 3957.
PubChem Substance IDSID 192028.
SuperDrug ATC IDR06AX13
SuperDrug CAS ID079794755;
TargetHistamine H1 receptorAntagonist[2][3][4]
Ref 1Desloratadine treatment for intermittent and persistent allergic rhinitis: a review. Clin Ther. 2007 Sep;29(9):1795-802. To Reference
Ref 2Clinical research of Ibudilast on treating the steroid resistant allergic rhinitis. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jan;23(2):63-6. To Reference
Ref 3Second-generation antihistamines: a comparative review. Drugs. 1999 Jan;57(1):31-47. To Reference
Ref 4Effect of descarboethoxyloratadine, the major metabolite of loratadine, on the human cardiac potassium channel Kv1.5. Br J Pharmacol. 1997 Nov;122(5):796-8. To Reference



 

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