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TTD Drug ID: DAP000105

Drug Information
NameAtracurium
SynonymsIsoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-; DB00732; AC1L2HUF; CHEBI:2914; AB00514743; SPBio_001930; LS-86151; 64228-79-1; 2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium]; Isoquinolinium, 1,2,3,4-tetrahydro-2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-2-methyl-; CID47319; 64228-81-5 (besylate); Prestwick2_000005; 5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate; BRN 1523633; UNII-2GQ1IRY63P; AC1Q67HR; C53H70N2O12; BPBio1_000011; Atracurium; Prestwick1_000005; CHEMBL1360; Atracurium Dibesylate; MolPort-005-932-641; HMS2090I21; C07548; Isoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl))-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-; BSPBio_000009; Prestwick3_000005
Trade NameTracrium
CompanyBurroughs Wellcome Co
IndicationGeneral anesthesia
[ICD9: 338   ICD10: R52]
Approved    [1]
Structure

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InChI1S/C53H72N2O12/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)2
8-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67
-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-
37-15-17-45(59-4)47(31-37)61-6/h14-17,30-35,42-43H,11-13,18-29H2,
1-10H3/q+2
InChIKeyYXSLJKQTIDHPOT-UHFFFAOYSA-N
Canonical SMILESC[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC
[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C    
Therapeutic ClassNeuromuscular Nondepolarizing Agents
CAS NumberCAS 64228-79-1
FormulaC53H72N2O12
PubChem Compound IDCID 47319.
PubChem Substance IDSID 9751.
SuperDrug ATC IDM03AC04
SuperDrug CAS ID064228791;
TargetNeuronal acetylcholine receptorAntagonist[2][3][4]
Ref 1A preliminary assessment of atracurium, a new competitive neuromuscular blocking agent. Acta Anaesthesiol Scand. 1981 Feb;25(1):67-9. To Reference
Ref 2Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. To Reference
Ref 3Neuromuscular block. Br J Pharmacol. 2006 Jan;147 Suppl 1:S277-86. To Reference
Ref 4Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine. Anesthesiology. 2001 Apr;94(4):643-51. To Reference



 

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