Therapeutic Targets Database
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TTD Drug ID: DAP000150

Drug Information
NameMilrinone
Synonyms1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile; Milrila; NCGC00015675-07; CHEMBL189; AC1Q2EBX; Primacor; Lopac-M-4659; D00417; NCGC00025189-02; Corotrop; 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile; Milrinonum; NCGC00015675-02; LS-44610; 3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone; HMS2090J14; CPD000058475; PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER; M4659_SIGMA; 111GE027; Milrinone [USAN:BAN:INN]; AB00514027; Prestwick2_001065; MLS000028818; C12H9N3O; SPBio_002965; UNII-JU9YAX04C7; CID4197; NCGC00025189-03; 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile; SAM001246611; AC1L1HMP; NCGC00015675-01; HMS1571E12; 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile; AC-4730; NCGC00164390-01; Milrila (TN); Win-47203; Milrinone (JAN/USAN/INN); Prestwick0_001065; SMR000058475; 1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile; BIDD:GT0197; Milrinona [Spanish]; WIN 47203-2; ZINC09224016; Milrinonum [Latin]; BSPBio_001050; C07224; Prestwick3_001065; 1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile; HMS2051L10; Tocris-1504; (3,4'-Bipyridine)-5-carbonitrile, 6-dihydro-2-methyl-6-oxo-; BRN 3546821; CAS-78415-72-2; Prestwick1_001065; NCGC00015675-04; Corotrope; DB00235; Win-47203-2; CHEBI:50693; YM 018; milrinone; I06-0259; S2484_Selleck; EN002063; MLS001424052; EU-0100737; Milrinona; M1663; 78415-72-2; BPBio1_001156; NCGC00025189-01; 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile; MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER; EINECS 278-903-6; Lopac0_000737; CCRIS 3795; M 4659; 6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile; SBB055743; (3,4'-BIPYRIDINE)-5-CARBONITRILE, 1,6-DIHYDRO-2-METHYL-6-OXO-
Trade NamePrimacor
CompanySanofi-Synthelabo Inc
IndicationCongestive heart failure
[ICD9: 428.0   ICD10: I50]
Approved    [1]
Structure

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InChI1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3
,(H,15,16)
InChIKeyPZRHRDRVRGEVNW-UHFFFAOYSA-N
Canonical SMILESCC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2    
Therapeutic ClassCardiotonic Agents
CAS NumberCAS 78415-72-2
FormulaC12H9N3O
PubChem Compound IDCID 4197.
PubChem Substance IDSID 9433.
ChEBI50693;
SuperDrug ATC IDC01CE02
SuperDrug CAS ID078415722;
TargetPhosphodiesterase 3, cGMP-inhibitedInhibitor[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Milrinone inhibits hypoxia or hydrogen dioxide-induced persistent sodium current in ventricular myocytes. Eur J Pharmacol. 2009 Aug 15;616(1-3):206-12. Epub 2009 Jun 21. To Reference



 

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