Therapeutic Targets Database
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TTD Drug ID: DAP000161

Drug Information
NameSparfloxacin
SynonymsZagam (TN); PD131501; 3-Quinolinecarboxylic acid, 1,4-dihydro-5-amino-1-cyclopropyl-6,8-difluoro-7-(3,5-dimethyl-1-piperazinyl)-4-oxo-, cis-; PD 1315-1; 5-Amino-1-cyclohexyl-7-(cis-3,5-dimethylpiperazino)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; C19H22F2N4O3; Sparfloxacin [USAN:BAN:INN:JAN]; CI 978; 3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-((3R,5S)-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-, rel-; D00590; MolPort-002-507-759; Sparfloxacinum [INN-Latin]; 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; SPFX; 33967_FLUKA; Esparfloxacino; 3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-, cis-; 110871-86-8; sparfloxacin, cis-isomer; Sparfloxacin (JAN/USAN/INN); (cis)-5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; PD-131501; 111542-93-9; CHEBI:9212; DB01208; 5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Spara; HMS2090N19; STK802067; Liposome-encapsulated sparfloxacin; Sparfloxacinum; 56968_FLUKA; BB_SC-1127; BRN 3658018; Esparfloxacino [INN-Spanish]; Zagam; AT-4140; 33967_RIEDEL; SMR000466312; AT 4140; AC1Q29E9; CPD000466312; Sparfloxacine [INN-French]; CI-978; 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl)-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid & RU 40555; Sparfloxacin & RU 40555; CP-103826; CHEMBL850; AC1L1TB5; PD 131501; MLS000759417; C07662; 56968_SIGMA; AC-11574; Sparfloxacine; I06-1320; CP 103826; sparfloxacin; NCGC00166294-01; UNII-Q90AGA787L; 5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid; RP-64206; DRG-0143; LS-141521; CID60464; SAM001246566; 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)- 6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Trade NameZagam; Zagam Respipac
CompanySquare pharma
IndicationBacterial infections
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
Approved    [1]
Structure

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InChI1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)2
1)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H
,27,28)/t8-,9+
InChIKeyDZZWHBIBMUVIIW-DTORHVGOSA-N
Canonical SMILESCC1CN(CC(N1)C)C2=C(C3=C(C(=C2F)N)C(=O)C(=CN3C4CC4)C(=O)O)F    
Isomeric SMILESC[C@@H]1CN(C[C@@H](N1)C)C2=C(C3=C(C(=C2F)N)C(=O)C(=CN3C4CC4)C(=O)O)F
Therapeutic ClassAnti-Bacterial Agents
CAS NumberCAS 110871-86-8
FormulaC19H22F2N4O3
PubChem Compound IDCID 60464.
PubChem Substance IDSID 9864.
ChEBI9212;
SuperDrug ATC IDJ01MA09
SuperDrug CAS ID110871868;
TargetDNA topoisomerase IIInhibitor[2]
DNA topoisomerase IIMultitarget[2]
Topoisomerase IVInhibitor[2]
Topoisomerase IVMultitarget[2]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020677 To Reference
Ref 2DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. To Reference



 

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