Therapeutic Targets Database
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TTD Drug ID: DAP000184

Drug Information
NameNevirapine
SynonymsMLS000084585; C07263; CHEMBL57; MLS001055309; 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one & PRO 140 (Anti-CCR5 monoclonal antibody); HMS2051J09; NCGC00065890-02; CPD000048458; BIRG-0587; Nevirapine & PRO 140; 1vrt; 129618-40-2; SAM001246551; 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one; HSDB 7164; BI RG 587; STK580320; BI-RG-587; DB08311; N11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one & CD4-immunoadhesin; BIDD:GT0326; MLS000759409; UNII-99DK7FVK1H; NVP; NON-NUCLEOSIDE RT INHIBITOR NEVIRAPINE; NEV; Nevirapine (JAN/USP/INN); D00435; BI-RG-587 & CD4-IgG; NSC641530; S1742_Selleck; Cahill May Roberts Brand of Nevirapine; SMR000048458; BIRG-587; Promeco Brand of Nevirapine; BIRG587; DB00238; I02-0310; 2hny; nevirapine; Viramune (TN); Bio-0789; 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE; CHEBI:44659; 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one; LS-2289; CID4463; Viramune, BI-RG 587, Nevirapine; AC-643; 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one; Viramune; BIRG 0587; C15H14N4O; ZINC00004778; 6H-Dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl-; 5H-Dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one, 5,11-dihydro-11-cyclopropyl-4-methyl-; D019829; Nevirapine & CD4-IgG; BIRG 587; Nevirapine [USAN:INN]; Viramune(TM); AC1L1I81; MolPort-002-507-817; MLS001201730; NSC 641530
Trade NameViramune
CompanyBoehringer Ingelheim
IndicationHIV infection
[ICD9: 042   ICD10: B20]
Approved    [1]
Structure

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InChI1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14
)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
InChIKeyNQDJXKOVJZTUJA-UHFFFAOYSA-N
Canonical SMILESCC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4    
Therapeutic ClassAnti-HIV Agents
CAS NumberCAS 129618-40-2
FormulaC15H14N4O
PubChem Compound IDCID 4463.
PubChem Substance IDSID 9472.
SuperDrug ATC IDJ05AG01
SuperDrug CAS ID129618402;
TargetNonnucleoside reverse transcriptaseInhibitor[2][3][4]
Ref 1Approved antiretroviral drugs. 2009 To Reference
Ref 2The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs. J Virol. 2009 Apr;83(8):3826-33. Epub 2009 Feb 4. To Reference
Ref 3Nevirapine Increases High-Density Lipoprotein Cholesterol Concentration by Stimulation of Apolipoprotein A-I Production. Arterioscler Thromb Vasc Biol. 2009 Aug 10. [Epub ahead of print] To Reference
Ref 4Mini Rev Med Chem. 2007 Nov;7(11):1108-19.Privileged structures: a useful concept for the rational design of new lead drug candidates. To Reference



 

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