Therapeutic Targets Database
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TTD Drug ID: DAP000192

Drug Information
NameDoxorubicin
SynonymsAdriamycin semiquinone; Doxorubicine [INN-French]; LMPK13050001; Adriamycin RDF (hydrochloride salt); EINECS 245-495-6; Aerosolized Doxorubicin; Adriacin (hydrochloride salt); Prestwick3_000438; Prestwick0_000438; 14-Hydroxydaunorubicine; Probes2_000129; CHEMBL179; MLS000759533; Hydroxydaunomycin hydrochloride (hydrochloride salt); Doxorubicin-hLL1; D03899; ThermoDox; Doxorubicin citrate; 23257-17-2; Doxorubicin-P4/D10 conjugate; 111266-55-8; 25316-40-9 (hydrochloride); NChemBio.2007.10-comp13; 24385-08-8; Prestwick1_000438; Adriblastina (TN); ADM; adriablatina (hydrochloride salt); LS-165655; NDC 38242-874; CHEBI:28748; CCRIS 739; Doxorubicina [INN-Spanish]; Triferric doxorubicin; DOX-SL; FI 106; DB00997; BSPBio_001031; Probes1_000151; Myocet; SPBio_002395; TLC D-99; Prestwick2_000438; LS-1029; Doxorubicin hydrochloride (hydrochloride salt); Adriablastin; CID31703; Doxorubicin-P4/D10; NCI-C01514; RDF Rubex; Doxorubicin-hLL1 conjugate; adriablastine (hydrochloride salt); Doxorubicin (USAN/INN); Doxorubicinum [INN-Latin]; NSC 123127; Adriblastin; Adriblas tina; 25311-50-6; Doxil; 25316-40-9; AC1L1M5T; Farmablastina (hydrochloride salt); 29042-30-6; Adriamycin PFS (hydrochloride salt); Doxorubicin [USAN:INN:BAN]; adr iablatina (hydrochloride salt); C01661; Adriblastina (hydrochloride salt); JT9100000; DM2; Doxorubicine; Rubex (hydrochloride salt); Adriamycin RDF; BSPBio_000456; BPBio1_000502; Hydroxydaunomycin hydrochlor ide (hydrochloride salt); Doxorubicin Hydrochloride; AC1Q29OJ; Doxorubicina; Resmycin; Conjugate of doxorubicin with humanized monoclonal antibody LL1 against CD74; nchembio809-comp5; 14-Hydroxydaunomycin; Adriamycin; 23214-92-8; HSDB 3070; Rubex; UNII-80168379AG; NIOSH/JT9100000; Adriblastina; doxorubicin; Conjugate of doxorubicin with monoclonal antibody P4/D10 against GP120; adriblatina (hydrochloride salt); Adriamycin PFS; C27H29NO11; SMP1_000106; ADR; Hydroxydaunorubicin hydrochloride (hydrochloride salt); adiblastine (hydrochloride salt); BRD-K92093830-003-04-3; Doxorubicinum; HMS2089H06
Trade NameAdriamycin PFS; Adriamycin RDF; Rubex; Caelyx; Myocet
CompanySequus Pharmaceuticals Inc
IndicationCancers
[ICD9: 140-229   ICD10: C00-C96]
Approved    [1]
Structure

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InChI1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-
29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)2
5(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,1
3-,15-,17-,22+,27-/m0/s1
InChIKeyAOJJSUZBOXZQNB-TZSSRYMLSA-N
Canonical SMILESCC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)
CO)O)N)O    
Isomeric SMILESC[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=
C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 23214-92-8
FormulaC27H29NO11
PubChem Compound IDCID 31703.
PubChem Substance IDSID 4809.
ChEBI28748;
SuperDrug ATC IDL01DB01
SuperDrug CAS ID023214928;
TargetDNA topoisomerase IIInhibitor[2][3]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J Biol Chem. 2008 Aug 29;283(35):23711-20. Epub 2008 Jul 2. To Reference
Ref 3Proteasome inhibition circumvents solid tumor resistance to topoisomerase II-directed drugs. Cancer Res. 2000 May 1;60(9):2429-34. To Reference



 

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