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TTD Drug ID: DAP000196

Drug Information
NameCisatracurium Besylate
SynonymsLS-178337; C53H72N2O12.2C6H5O3S; (1R-cis,1'R-cis)-Atracurium besylate; D00759; Atracurium besylate 1R-cis,1R'-cis form; Nimbex Forte; Cisatracurium besilate; benzenesulfonate; 5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate; Cisatracurium; UNII-80YS8O1MBS; Cisatracurium besylate (USAN); CHEBI:3721; (1R,2R)-2-(2-Carboxyethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium benzenesulfonate, pentamethylene ester; NCGC00017127-01; MolPort-003-987-490; AC1L1XZG; Nimbium; Cisatracurium besylate [USAN:BAN]; CAS-64228-81-5; AC1Q22ND; TL8006016; Cisatracurium besilate (INN); CID62886; Nimbex; DB00565; Isoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, dibenzenesulfonate, (1R-(1alpha,2alpha(1'R(sup *),2'R(sup *))))-; cisatracurium besylate(usan); CHEMBL1200641; 51W89; NIMBEX PRESERVATIVE FREE; 96946-42-8; Nimbex (TN); Cisatracurium besylate
Trade NameNimbex
CompanyAbbott Laboratories
IndicationGeneral anesthesia
[ICD9: 338   ICD10: R52]
Approved    [1]
Structure

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InChI1S/C53H72N2O12.2C6H6O3S/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(3
8)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11
-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)
43(55)29-37-15-17-45(59-4)47(31-37)61-6;2*7-10(8,9)6-4-2-1-3-5-6/
h14-17,30-35,42-43H,11-13,18-29H2,1-10H3;2*1-5H,(H,7,8,9)/q+2;;/p
-2/t42-,43-,54-,55-;;/m1../s1
InChIKeyXXZSQOVSEBAPGS-DONVQRBFSA-L
Canonical SMILESC[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC
[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=
O)[O-].C1=CC=C(C=C1)S(=O)(=O)[O-]    
Isomeric SMILESC[N@@+]1(CCC2=CC(=C(C=C2[C@H]1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC
(=O)CC[N@+]4(CCC5=CC(=C(C=C5[C@H]4CC6=CC(=C(C=C6)OC)OC)OC)OC)C.C1=CC=C
(C=C1)S(=O)(=O)[O-].C1=CC=C(C=C1)S(=O)(=O)[O-]
Therapeutic ClassNeuromuscular Blocking Agents
CAS NumberCAS 96946-42-8
FormulaC65H82N2O18S2
PubChem Compound IDCID 62886.
PubChem Substance IDSID 205074.
SuperDrug ATC IDM03AC11
SuperDrug CAS ID096946428;
TargetNeuronal acetylcholine receptorAntagonist[2][3]
Ref 1Synthesis and structure-activity relationships of neuromuscular blocking agents. Curr Med Chem. 2002 Aug;9(16):1507-36. To Reference
Ref 2Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. To Reference
Ref 3Comparative study of neuromuscular blocking and hemodynamic effects of rocuronium and cisatracurium under sevoflurane or total intravenous anesthesia. Middle East J Anesthesiol. 2009 Feb;20(1):39-51. To Reference



 

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