Therapeutic Targets Database
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TTD Drug ID: DAP000222

Drug Information
NameCisapride
SynonymsBenzamide, 4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy-4-piperidinyl)-2-methoxy-, cis-; 86718-68-5; Cisawal; Kinestase; R-51619; Rapulid; Benzamide, 4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy -4-piperidinyl)-2-methoxy-, cis-; CID2769; HMS1569E22; Kaudalit; T 1341; R 51619; Risamol; L000938; UNII-UVL329170W; cisapride; Prestwick0_000430; Vomiprid; (+-)-Cisapride; Cisaprida [Spanish]; I01-0115; Cisapridum [Latin]; STL058624; MolPort-003-666-853; Pridesia; Unamol; Propulsid; EINECS 279-689-7; C06910; Cisaprida [INN-Spanish]; Prepulsid; Syspride; Vomipride; Propulsin; Cisapron; Dispep; Acenalin; C23H29ClFN3O4.H2O; Alimix Forte; SPBio_002359; Unipride; Prestwick2_000430; NCGC00168465-01; 4-amino-5-chloro-N-[1-{3-[(4-fluorophenyl)oxy]propyl}-3-(methyloxy)piperidin-4-yl]-2-(methyloxy)benzamide; AC-1912; Benzamide, 4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy-4-piperidinyl)-2-methoxy-, monohydrate, cis-; Risamal; Enteropride; Cisaprida; 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide; Prestwick1_000430; AC1L1EFB; LS-25437; DB00604; Cipride; Propulsid Quicksolv; Alipride; Alimix; D00274; HSDB 3571; 4-amino-5-chloro-N-{1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide; Pulsid; Cisapridum; Colinorm; 81098-60-4; Acpulsif; Cisapride [USAN:BAN:INN:JAN]; Guptro; Cisapride (USAN/INN); Cisapridum [INN-Latin]; Prestwick_786; Esorid; cis-4-Amino-5-chloro-N-(1-(3-(p-fluorophenoxy)propyl)-3-methoxy-4-piperidyl)-o-anisamide; Presid; Benzamide, 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, cis-
Trade NamePrepulsid; Propulsid
CompanyJanssen Pharmaceutica
IndicationGastroesophageal reflux disease
[ICD9: 530   ICD10: K21]
Approved    [1]
Structure

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InChI1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-1
0-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22
H,3,8-11,14,26H2,1-2H3,(H,27,29)
InChIKeyDCSUBABJRXZOMT-UHFFFAOYSA-N
Canonical SMILESCOC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F    
Therapeutic ClassGastrointestinal Agents
CAS NumberCAS 81098-60-4
FormulaC23H29ClFN3O4
PubChem Compound IDCID 2769.
PubChem Substance IDSID 9127.
SuperDrug ATC IDA03FA02
SuperDrug CAS ID081098604;
Target5-hydroxytryptamine 4 receptorAgonist[2][3]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020210 To Reference
Ref 2Metoclopramide stimulates catecholamine- and granin-derived peptide secretion from pheochromocytoma cells through activation of serotonin type 4 (5-HT4) receptors. Endocr Relat Cancer. 2009 Mar;16(1):281-90. Epub 2008 Oct 23. To Reference
Ref 3The in vivo gastrointestinal activity of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):139-47. Epub 2008 Apr 12. To Reference



 

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