Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DAP000236

Drug Information
SynonymsMolPort-005-933-986; Lopac-A-0779; C07668; 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine; Iopidine Eye; Apraclonidine [INN:BAN]; Iopidine (TN); ZINC00020231; MolPort-003-940-020; Lopac0_000033; CHEBI:2788; Apraclonidina; DB00964; D07461; CHEBI:127495; L013394; 4-Aminoclonidine; C9H10Cl2N4; 2-(4-Amino-2,6-dichloroanilino)-2-imidazoline hydrochloride; 2,6-dichloro-N(1)-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; CID2216; NCGC00015033-03; 1,4-Benzenediamine, 2,6-dichloro-N'-(4,5-dihydro-1H-imidazol-2-yl)-; 66711-21-5; AC1L1D6L; UNII-843CEN85DI; Apraclonidine (INN); ALO 2145; NCGC00162050-01; AC-12697; Apraclonidinum [INN-Latin]; CHEMBL647; PDSP2_000778; 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; NCGC00015033-01; SMP1_000016; para-aminoclonidine; Apraclonidinum; LS-176536; apraclonidine; Aplonidine; Iopidine; A0779_SIGMA; PDSP1_000790; Apraclonidina [INN-Spanish]; L000686; p-aminoclonidine
CompanyAlcon Canada Inc
IndicationAdditional Intra Ocular Pressure (IOP) reductionApproved    [1]

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Canonical SMILESC1CN=C(N1)NC2=C(C=C(C=C2Cl)N)Cl    
Therapeutic ClassAntiglaucomic Agents
CAS NumberCAS 66711-21-5
PubChem Compound IDCID 2216.
PubChem Substance IDSID 9870.
SuperDrug ATC IDS01EA03
SuperDrug CAS ID066711215;
TargetAlpha-2 adrenergic receptorAgonist[2][3]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Apraclonidine attenuates the increases in spinal excitatory amino acid release in rats with adjuvant-induced inflammation. Anesth Analg. 2002 Mar;94(3):701-5; table of contents. To Reference
Ref 3Topically applied clonidine protects the rat retina from ischaemia/reperfusion by stimulating alpha(2)-adrenoceptors and not by an action on imidazoline receptors. Brain Res. 2001 Jun 15;904(1):126-36. To Reference


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