Therapeutic Targets Database
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TTD Drug ID: DAP000337

Drug Information
NameCyclizine
SynonymsHMS2091I08; NSC 26608; Wellcome preparation 47-83; Spectrum_000854; BRD-K79501723-001-02-0; HSDB 3309; LS-111945; SPECTRUM1500211; NCGC00094634-02; KBio1_001957; KBioSS_001334; Prestwick2_000510; DivK1c_007013; Valoid; Ciclizina; 1-Diphenylmethyl-4-methylpiperazine; 5-23-01-00232 (Beilstein Handbook Reference); Wellcome; Prestwick3_000510; Spectrum3_000368; Compound 47-83; Marezine hydrochloride; C06930; 1-(Diphenylmethyl)-4-methylpiperazine; KBio2_003902; AC1L1N61; 1-Benzhydryl-4-methylpiperazine; WLN: T6N DNTJ AYR&R& D1; N-Methyl-N'-benzhydrylpiperazine; SpecPlus_000917; BRN 0230441; Cyclizinum [INN-Latin]; BW 47-83; AC1Q3ZTI; Reis-fit; EINECS 201-445-5; Spectrum4_000205; Wellcome prepn. 47-83; Nautazine; Emoquil; BSPBio_000439; Ciclizina [INN-Spanish]; N-Methyl-N'-benzyhydrylpiperazine; Spectrum5_001594; CHEMBL648; NSC26608; CYCLIZINE; CHEBI:3994; 82-92-8; NCGC00016421-01; Neo-devomit; CID6726; DB01176; BSPBio_002095; (+-)-1-diphenylmethyl-4-methylpiperazine; BPBio1_000483; UNII-QRW9FCR9P2; KBioGR_000809; SPBio_001187; Prestwick0_000510; KBio3_001315; KBio2_001334; HMS1920A20; Cyclizine hydrochloride; N-Benzhydryl-N'-methylpiperazine; Cyclizinum; Spectrum2_001174; CAS-303-25-3; KBio2_006470; L000701; Oprea1_429421; NCGC00094634-01; SPBio_002360; Cyclizine [INN:BAN:DCF]; Piperazine, 1-(diphenylmethyl)-4-methyl-; Ne-devomit; D03621; (N-Benzhydryl)(N'-methyl)diethylenediamine; 1-Benzhydryl-4-methylpiperazin; Wellcome prepn 47-83; BRD-K79501723-003-03-4; Marezine; Cyclizine chloride; Prestwick1_000510; ( -)-1-Diphenylmethyl-4-methylpiperazine; MolPort-001-798-137; Cyclizine (INN); AB00053084
Trade NameValoid; Marezine; Marzine; Emoquil
CompanySeatrace Pharmaceuticals
IndicationNausea and vomiting
[ICD9: 787, 787.0   ICD10: R11]
Approved    [1]
Structure

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InChI1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-
7-11-17/h2-11,18H,12-15H2,1H3
InChIKeyUVKZSORBKUEBAZ-UHFFFAOYSA-N
Canonical SMILESCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3    
Therapeutic ClassAntiemetics
CAS NumberCAS 82-92-8
FormulaC18H22N2
PubChem Compound IDCID 6726.
PubChem Substance IDSID 9147.
ChEBI3994;
SuperDrug ATC IDR06AE03
SuperDrug CAS ID000082928;
TargetHistamine H1 receptorAntagonist[2][3][4]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009495 To Reference
Ref 2Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. Ther Drug Monit. 2003 Apr;25(2):192-6. To Reference
Ref 3Comparison of cyclizine and ondansetron for the prevention of postoperative nausea and vomiting in laparoscopic day-case gynaecological surgery. Anaesthesia. 2002 Jan;57(1):61-5. To Reference
Ref 4Synthesis and combined H1-/H2 antagonist activity of mepyramine, pheniramine and cyclizine derivatives with cyanoguanidine, urea and nitroethenediamine partial structures. Arch Pharm (Weinheim). 1994 Jul;327(7):455-62. To Reference



 

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