Therapeutic Targets Database
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TTD Drug ID: DAP000344

Drug Information
NameTiotropium
Synonyms3-Oxa-9-azoniatricyclo(3,3.1.0(2,4))nonane, 7-((hydroxydi-2-thienylacetyl)oxy)-9,9-dimethyl-, bromide, (1alpha,2beta,4beta,5alpha,7beta)-; CID5487427; AC-1300; LS-172955; (1|A,2|A,4|A,5|A,7|A)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatri-cyclo[3.3.1.02.4]nonane bromide; (1a,2,4,5a,7)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide; BA-679 BR; 186691-13-4; TIOTROPIUM BROMIDE; Spiriva Respimat; AC1L1U0B; MolPort-005-935-362; BA 679BR; MolPort-006-396-155; Tiotropium; 3-oxa-9-azoniatricyclo(3,3.1.0(2,4))nonane,7-((hydroxydi-2-thienylacetyl)oxy)9,9-dimethyl-,bromide,(1alpha,2beta,4beta,5alpha,7beta)-; BA-679-BR; HMS2090H20; 7-((Hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane bromide; AC1Q1RHA; UNII-0EB439235F; Spiriva; BA 679 BR; C19H22NO4S2; Tiotropium bromide [USAN:INN]; Spiriva Handihaler; 7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide; UNII-XX112XZP0J; ZINC13900863; 136310-93-5; CID60830; NCGC00167971-01; AB1004875
Trade NameSpiriva
CompanyBoehringer Ingelheim
IndicationChronic obstructive pulmonary disease
[ICD9: 490-492, 494-496   ICD10: J40-J44, J47]
Approved    [1]
Structure

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InChI1S/C19H22NO4S2.BrH/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(
21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;/h3-8,11-13,16-17,22H,9-10
H2,1-2H3;1H/q+1;/p-1
InChIKeyDQHNAVOVODVIMG-UHFFFAOYSA-M
Canonical SMILESC[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C.[Br-]    
Therapeutic ClassBronchodilator Agents
CAS NumberCAS 186691-13-4
FormulaC19H22BrNO4S2
PubChem Compound IDCID 60830.
PubChem Substance IDSID 197073.
SuperDrug ATC IDR03BB04
SuperDrug CAS ID136310935;
TargetMuscarinic acetylcholine receptor M3Antagonist[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29. To Reference



 

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