Therapeutic Targets Database
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TTD Drug ID: DAP000380

Drug Information
NameNalbuphine
SynonymsD08246; Prestwick0_000118; BPBio1_000150; HMS2089I04; Nalbufina; BSPBio_000136; (5alpha,6alpha)-17-(cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol; Nalbuphinum; Intapan (TN); SPBio_002075; Prestwick2_000118; 20594-83-6; nalbuphine; Prestwick3_000118; Prestwick1_000118; CHEMBL895; 17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alpha,14-triol; CHEBI:7454; C07251; CID5311304; BRD-K66404838-003-03-8; BIDD:GT0060; Nalbuphine (INN); Intapan
Trade NameNubain
CompanyEndo Pharmaceuticals
IndicationPain
[ICD9: 338,780   ICD10: R52, G89]
Approved    [1]
Structure

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InChI1S/C21H27NO4/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)1
8(14)26-19)8-9-22(16)11-12-2-1-3-12/h4-5,12,15-16,19,23-25H,1-3,6
-11H2/t15-,16+,19-,20-,21+/m0/s1
InChIKeyNETZHAKZCGBWSS-CEDHKZHLSA-N
Canonical SMILESC1CC(C1)CN2CCC34C5C(CCC3(C2CC6=C4C(=C(C=C6)O)O5)O)O    
Isomeric SMILESC1CC(C1)CN2CC[C@]34[C@@H]5[C@H](CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O)O
Therapeutic ClassAnalgesics
CAS NumberCAS 20594-83-6
FormulaC21H27NO4
PubChem Compound IDCID 5311304.
PubChem Substance IDSID 9460.
ChEBI7454;
SuperDrug ATC IDN02AF02
SuperDrug CAS ID020594836;
TargetDelta-type opioid receptorAntagonist[2]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 070692 To Reference
Ref 2Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors. J Med Chem. 2007 May 3;50(9):2254-8. Epub 2007 Apr 4. To Reference



 

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