Therapeutic Targets Database
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TTD Drug ID: DAP000396

Drug Information
NameTeriparatide
Synonyms52232-67-4; Forteo; Teriparatide (genetical recombination); Teriparatide (genetical recombination) (JAN); Teriparatide (USAN/INN); Forteo (TN); D06078; TERIPARATIDE
Trade NameForteo
CompanyEli Lilly and Company
IndicationOsteogenesis imperfecta
[ICD9: 756.51   ICD10: Q78.0]
Approved    [1]
Structure

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InChI1S/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250
)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)
103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(
65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-
196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-
88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223
-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)2
25-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-6
1-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-
60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52
-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)
104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(19
1)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58
-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)
154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)2
29-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)17
0(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77
-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,1
82-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(
H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245
)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,26
9)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,2
76)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,
256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229
,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,23
5,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,2
86,287)(H4,191,192,198)(H4,193,194,199)
InChIKeyOGBMKVWORPGQRR-UHFFFAOYSA-N
Canonical SMILESCCC(C)C(C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(CC1=CNC=N1)
C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC2=CNC=N2)C
(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C
(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CNC4=CC=CC=
C43)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)
NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NC(CC5=
CNC=N5)C(=O)NC(CC(=O)N)C(=O)NC(CC6=CC=CC=C6)C(=O)O)NC(=O)C(CCC(=O)O)NC(=
O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CO)N    
Therapeutic ClassBone Density Conservation Agents
CAS NumberCAS 52232-67-4
FormulaC181H291N55O51S2
PubChem Compound IDCID 16129682.
PubChem Substance IDSID 181193.
SuperDrug ATC IDH05AA02
SuperDrug CAS ID052232674;
TargetParathyroid hormone/parathyroid hormone-related peptide receptorBinder[2][3][4]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Parathyroid hormone, its fragments and their analogs for the treatment of osteoporosis. Treat Endocrinol. 2002;1(3):175-90. To Reference
Ref 3The N-terminal fragment of human parathyroid hormone receptor 1 constitutes a hormone binding domain and reveals a distinct disulfide pattern. Biochemistry. 2000 Aug 1;39(30):8878-87. To Reference
Ref 4A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science. 1995 Apr 7;268(5207):98-100. To Reference



 

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