Therapeutic Targets Database
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TTD Drug ID: DAP000414

Drug Information
NameVardenafil
SynonymsHMS2089K04; 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one; DB00862; Levitra (TN); BRD-K13926615-003-01-7; CID110634; VARDENAFIL, LEVITRA; MolPort-005-975-775; BAY38-9456; STOCK6S-20068; S2515_Selleck; BAY 38-9456; VDN; 2-(2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl)-5-methyl-7-propyl-3H-imidazo(5,1-f)(1,2,4)triazin-4-one; LS-111467; UNII-UCE6F4125H; Piperazine, 1-((3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo(5,1-f)(1,2,4)triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethyl-; Vardenafil (INN); HSDB 7304; AC1L3808; CHEMBL1520; 1-((3-(3,4-Dihydro-5-methyl-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine; NCGC00167533-01; BSPBio_002392; 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4-ol; STK642629; 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE; 224785-90-4; Vardenafil; D08668; MolPort-002-672-272
Trade NameLevitra
CompanyBayer Pharmaceuticals Corporation
IndicationErectile dysfunction
[ICD9: 302.72, 607.84   ICD10: F52.2, N48.4]
Approved    [1]
Structure

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InChI1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15
-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H
,5-8,11-14H2,1-4H3,(H,25,26,30)
InChIKeySECKRCOLJRRGGV-UHFFFAOYSA-N
Canonical SMILESCCCC1=NC(=C2N1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C    
Therapeutic ClassAnti-Impotence Agents
CAS NumberCAS 224785-90-4
FormulaC23H32N6O4S
PubChem Compound IDCID 110634.
PubChem Substance IDSID 585745.
SuperDrug ATC IDG04BE09
SuperDrug CAS ID224785904;
TargetCGMP-specific 3',5'-cyclic phosphodiesteraseBinder[2]
Ref 1Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66. Epub 2007 Aug 27. To Reference
Ref 2The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease. J Am Coll Cardiol. 2002 Dec 4;40(11):2006-12. To Reference



 

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