Therapeutic Targets Database
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TTD Drug ID: DAP000461

Drug Information
NameTamibarotene
SynonymsAmnolake; Amnoid (TN); Amnoid; DB04942; N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl)-2-naphthyl)terephthalamic acid; 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid; FT-0080835; AM-80; UNII-08V52GZ3H9; AC1L33F5; N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)terephthalamic acid; Amnoleuk; Tamibarotene (JAN/INN); NSC 608000; TM-411; AC-7049; Am80; Tamibaro; NSC-608000; retinobenzoic acid; NSC608000; TOS-80; Benzoic acid, 4-(((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino)carbonyl)-; NCGC00181111-01; 4-(((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)amino)carbonyl)benzoic acid; Terephthalic acid mono-5,5,8,8-tetramethyl- 5,6,7, 8-tetrahydro-2-naphthylamide; 121GE003; 94497-51-5; C12864; Z-208; Tamibarotene; 2cbr; 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid; C061133; 4-((5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl)benzoic acid; CHEMBL25202; NCI60_004716; CHEBI:32181; LS-38350; I14-1960; Terephthalic acid mono-5,5,8,8-tetramethyl- 5,6,7,8-tetrahydro-2-naphthylamide; Am 80; D01418; CID108143
CompanySanofi-Aventis
IndicationLeukemia
[ICD9: 208.9   ICD10: C91-C95]
Approved    [1]
Structure

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InChI1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24
)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25
,26)
InChIKeyMUTNCGKQJGXKEM-UHFFFAOYSA-N
Canonical SMILESCC1(CCC(C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(=O)O)(C)C)C    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 94497-51-5
FormulaC22H25NO3
PubChem Compound IDCID 108143.
PubChem Substance IDSID 226593.
ChEBI32181;
TargetRetinoic acid receptor alphaBinder[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int J Oncol. 2007 Aug;31(2):397-404. To Reference



 

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