Therapeutic Targets Database
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TTD Drug ID: DAP000481

Drug Information
NameMetoprolol
SynonymsAstraZeneca Brand of Seloken; Dutoprol; Meijoprolol; 1-[(1-methylethyl)amino]-3-({4-[2-(methyloxy)ethyl]phenyl}oxy)propan-2-ol; Tartrate, Metoprolol; L000669; AstraZeneca Brand of Metaoprolol Tartrate; LOPRESSIDONE; Metoprololum; Spesikor; Preblok; Leiras Brand of Metoprolol Succinate or Metoprolol Tartrate; I06-0125; H 93 26; H 9326; 1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol; Jsp006606; Lopressor; CGP 2175; (RS)-Metoprolol; 37350-58-6; EINECS 253-483-7; NCGC00021148-03; 1-(Isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol; MolPort-005-938-039; 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (.+/-.)-; 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol; Toprol; Betalok; Selo-Zok; 1-[4-(2-methoxyethyl)phenoxy]-3-propan-2-ylamino-propan-2-ol; BRD-A03623303-045-02-0; Betaloc; Betaloc-Astra; Lopresoretic; NCGC00021148-04; Seloken AstraZeneca Brand; Metohexal; CHEMBL13; Beloc-Duriles; Beatrolol; Metoprololum [INN-Latin]; Metoprolol succinate; Beloc Duriles; D008790; AB00053499; dl-Metoprolol; 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-; AC1L1HKM; Presolol; LS-122450; AC-19022; CGP-2175; BetalocAstra; D02358; HSDB 6531; H 93-26; CHEBI:6904; I01-7125; CID4171; BelocDuriles; C07202; 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-; Betaloc Astra; EINECS 257-166-4; 51384-51-1; CGP2175; Novartis Brand of Metprolol Tartrate; 54163-88-1; UNII-GEB06NHM23; Metoprolol (USAN/INN); Spesicor; HMS2090B15; Seroken; Seloken; TOPROL-XL; CCRIS 4198; Metoprolol [USAN:INN:BAN]; Lopresor; Metroprolol; 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol; 3-[4-(2-methoxyethyl)phenoxy]-1-(propan-2-ylamino)propan-2-ol; NCGC00021148-02; DB00264; metoprolol
Trade NameLopressor; Toprol-XL; Selokeen; Minax; Metrol; Betaloc; Neobloc; Corvitol
CompanyAstraZeneca
IndicationHypertension
[ICD9: 401   ICD10: I10, I11, I12, I13, I15]
Approved    [1]
Structure

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InChI1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/
h4-7,12,14,16-17H,8-11H2,1-3H3
InChIKeyIUBSYMUCCVWXPE-UHFFFAOYSA-N
Canonical SMILESCC(C)NCC(COC1=CC=C(C=C1)CCOC)O    
Therapeutic ClassAntihypertensive Agents
CAS NumberCAS 37350-58-6
FormulaC15H25NO3
PubChem Compound IDCID 4171.
PubChem Substance IDSID 9411.
ChEBI6904;
SuperDrug ATC IDC07AB02
SuperDrug CAS ID037350586;
TargetBeta-1 adrenergic receptorAntagonist[2][3][4]
Ref 1The effect of food on the relative bioavailability of rapidly dissolving immediate-release solid oral products containing highly soluble drugs. Mol Pharm. 2004 Sep-Oct;1(5):357-62. To Reference
Ref 2Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia. Environ Toxicol Chem. 2005 Oct;24(10):2470-6. To Reference
Ref 3Nat Rev Drug Discov. 2003 Jan;2(1):38-51.Knockouts model the 100 best-selling drugs--will they model the next 100? To Reference
Ref 4Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404. To Reference



 

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