Therapeutic Targets Database
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TTD Drug ID: DAP000492

Drug Information
NamePirenzepine
SynonymsKBioGR_000794; Prestwick1_000129; NCGC00024297-05; MolPort-002-673-624; NCGC00015836-09; Spectrum2_001417; Gasteril; L-S 519; Pirenzepina; KBio3_002445; Prestwick2_000129; Spectrum3_001453; Pirenzepine (INN); Pirenzepinum; KBio2_004426; Lopac-P-7412; DB00670; Prestwick3_000129; 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-; KBio2_001858; NCGC00024297-04; LS-133128; AC1L1J3B; DivK1c_000127; Bio-0807; Prestwick0_000129; Pirenzepine [INN:BAN]; Ulcosan; Gastrozepin; NCGC00015836-01; D08389; Pirenzepinum [INN-Latin]; L000485; NCGC00015836-02; AB00053603; NCGC00024297-02; 28797-61-7; BSPBio_000178; CHEBI:8247; UNII-3G0285N20N; KBio2_006994; Pyrenzepine; SPBio_001494; KBio1_000127; IDI1_000127; EINECS 249-228-4; PDSP1_000965; NINDS_000127; BPBio1_000196; HMS2089K21; Spectrum4_000437; Pirenzepine Gastrozepin; 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one; Gastrotsepin; 11-((4-Methyl-1-piperazinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one; 6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-; NCGC00015836-03; Tocris-1071; C07508; Pirenzepina [INN-Spanish]; CID4848; CHEMBL9967; Spectrum5_001344; 5,11-Dihydro-11-((4-methyl-1-piperazinyl)acetyl)-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one; 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one; PDSP2_000949; Pirenzepin; Lopac0_000962; BRN 0628987; BSPBio_002945; Spectrum_001378; KBioSS_001858; BRD-K89375097-300-05-4; C19H21N5O2; SPBio_002117; pirenzepine; CAS-29868-97-1
Trade NameGastrozepin
CompanyBoehringer Ingelheim
IndicationPeptic ulcer disease
[ICD9: 531-534   ICD10: K25-K27]
Approved    [1]
Structure

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InChI1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16
)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
InChIKeyRMHMFHUVIITRHF-UHFFFAOYSA-N
Canonical SMILESCN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4    
Therapeutic ClassAnti-Ulcer Agents
CAS NumberCAS 28797-61-7
FormulaC19H21N5O2
PubChem Compound IDCID 4848.
PubChem Substance IDSID 9711.
ChEBI8247;
SuperDrug ATC IDA02BX03
SuperDrug CAS ID028797617;
TargetMuscarinic acetylcholine receptor M1Antagonist[2][3]
Ref 1Autonomic modulation during acute myocardial ischemia by low-dose pirenzepine in conscious dogs with a healed myocardial infarction: a comparison with beta-adrenergic blockade. J Cardiovasc Pharmacol. 2003 May;41(5):671-7. To Reference
Ref 2Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate. Neurosci Lett. 2009 Aug 14;459(3):127-31. Epub 2009 May 7. To Reference
Ref 3The effect of muscarinic receptor blockers on non-specific bronchial reactivity in patients with bronchial asthma. Pneumonol Alergol Pol. 1992;60(11-12):32-6. To Reference



 

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