Therapeutic Targets Database
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TTD Drug ID: DAP000523

Drug Information
NameLosartan
SynonymsAC1L1H3Q; HMS1922J13; DUP 89; Oprea1_644635; KBioSS_002193; Losartic; UNII-JMS50MPO89; BSPBio_002695; 114798-26-4; MK-954; KBio2_004761; (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol; losartan; 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol; LOSARTAN POTASSIUM; NCGC00095125-03; Spectrum_001713; D08146; LS-78746; Losartic (TN); [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol; Lortaan; 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole; BRD-K76205745-001-02-5; DB00678; (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol; Hyzaar; 1H-imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-; Spectrum2_001677; SPBio_001893; Jsp001094; 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl-1H-imidazole-5-methanol; NCGC00095125-01; Spectrum4_001126; Cozaar; Losartan [INN:BAN]; CID3961; 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI); Losartan monopotassium salt; Losartan (INN); 124750-99-8 (mono-potassium salt); CHEBI:6541; 2-n-butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]imidazole; 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'- biphenyl)-4-yl)methyl)-; BIDD:GT0286; HMS2093E22; KBio3_001915; KBio2_002193; L000351; SPECTRUM1504268; I14-9710; MK954; NCGC00095125-02; Spectrum3_000998; MolPort-003-666-553; Spectrum5_001466; CHEMBL191; C22H23ClN6O; KBioGR_001611; KBio2_007329; CL23623; 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-methanol; DuP-753; C07072
Trade NameCozaar
CompanyMerck & Co
IndicationHypertension
[ICD9: 401   ICD10: I10, I11, I12, I13, I15]
Approved    [1]
Structure

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InChI1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(
12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,1
3-14H2,1H3,(H,25,26,27,28)
InChIKeyPSIFNNKUMBGKDQ-UHFFFAOYSA-N
Canonical SMILESCCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl    
Therapeutic ClassAntihypertensive Agents
CAS NumberCAS 114798-26-4
FormulaC22H23ClN6O
PubChem Compound IDCID 3961.
PubChem Substance IDSID 9283.
ChEBI6541;
SuperDrug ATC IDC09CA01
SuperDrug CAS ID114798264;
TargetType-1 angiotensin II receptorAntagonist[2][3][4]
Ref 1New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. To Reference
Ref 2Radioligand binding assays: application of [(125)I]angiotensin II receptor binding. Methods Mol Biol. 2009;552:131-41. To Reference
Ref 3Nat Rev Drug Discov. 2003 Jan;2(1):38-51.Knockouts model the 100 best-selling drugs--will they model the next 100? To Reference
Ref 4Effect of episodic hypoxia on sympathetic activity and blood pressure. Respir Physiol. 2000 Feb;119(2-3):189-97. To Reference



 

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