Therapeutic Targets Database
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TTD Drug ID: DAP000561

Drug Information
NamePhysostigmine
SynonymsEserolein, methylcarbamate (ester); Spectrum2_001283; NSC 30782; Physostigmine [USAN:BAN]; NCGC00093889-01; Physostigmine (USP); Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-; EU-0100483; CCRIS 3422; KBio2_007414; KBioSS_001396; NIH 10421; RCRA waste no. P204; Prestwick3_000566; MolPort-001-683-926; SPBio_000774; Ezerin; Prestwick0_000566; Spectrum4_001631; Spectrum2_000330; 45710_FLUKA; NSC30782; NCGC00093889-04; Fysostigmin [Czech]; WLN: T B556 EN GNTT&J B1 E1 G1 KOVM1; KBio3_001689; MLS001304022; C06535; BSPBio_000352; Lopac0_000483; Spectrum3_000901; Spectrum_000916; Spectrum_001789; (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate; CPD-12048; NCGC00093889-05; KBio2_002278; HMS2089M11; KBio2_003964; Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-; 511-49-9; DB00981; Spectrum2_000757; SPECTRUM1500753; KBio2_001396; Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(N-methylcarbamate), (3aS,8aR)-; Esromiotin; Eserine (TN); BRD-K25650355-001-02-5; KBioGR_002533; UNII-9U1VM840SP; CHEBI:27953; SPBio_002571; 50975-37-6; KBio1_001421; KBio3_001842; NCGC00093889-06; Spectrum5_001672; KBioGR_001433; Calabarine; Eserine; AC1L1LJL; [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate; MEGxp0_001872; NCGC00093889-02; MCV 4484; (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-ol methylcarbamate (ester); Spectrum4_001913; Spectrum4_000997; Eserine sulfate; SDCCGMLS-0066585.P001; KBioGR_002061; DivK1c_006477; STOCK1N-03554; Fysostigmin; Methyl-carbamic acid, ester with eseroline; 1,2,3,3abeta,8abeta-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)-indol-5-yl methylcarbamate; NCGC00093889-03; Erserine; CID5983; BPBio1_000388; AC-15983; P0406; BRD-K25650355-059-02-3; HSDB 3161; SMR000718753; Physostol; E8375_SIGMA; Carbamic acid, methyl-, ester with eseroline; Eserolein, methylcarbamate; E 8375; CS 58525; KBio2_006532; EINECS 200-332-8; SpecPlus_000381; BSPBio_002189; HMS1921G06; KBio2_004846; Spectrum5_000626; Spectrum3_000545; KBioSS_002279; SPBio_001285; physostigmine; Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-; (-)-physostigmine; D010830; ACon1_000097; LS-109562; Antilirium; Prestwick2_000566; NCGC00093889-08; SPBio_000339; 57-47-6; D00196; CHEMBL94; Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis); Spectrum5_000441; Prestwick1_000566
Trade NameAntilirium; Eserine Salicylate; Isopto Eserine; and Eserine Sulfate
IndicationGlaucoma
[ICD9: 365   ICD10: H40-H42]
Approved    [1]
Structure

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InChI1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-1
4(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1
InChIKeyPIJVFDBKTWXHHD-HIFRSBDPSA-N
Canonical SMILESCC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C    
Isomeric SMILESC[C@@]12CCN([C@@H]1N(C3=C2C=C(C=C3)OC(=O)NC)C)C
Therapeutic ClassMiotics
CAS NumberCAS 57-47-6
FormulaC15H21N3O2
PubChem Compound IDCID 5983.
PubChem Substance IDSID 8765.
ChEBI27953;
SuperDrug ATC IDS01EB05; V03AB19
SuperDrug CAS ID000057476;
TargetAcetylcholinesteraseInhibitor[2][3]
Ref 1Physostigmine as a treatment for gamma-hydroxybutyrate toxicity: a review. J Toxicol Clin Toxicol. 2002;40(6):781-7. To Reference
Ref 2Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. Behav Brain Res. 2009 Oct 12;203(1):1-14. Epub 2009 Mar 28. To Reference
Ref 3Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent subchronic administration of donepezil: role of sigma-1 receptors. Brain Res. 2009 Jul 7;1279:189-96. Epub 2009 May 9. To Reference



 

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