Therapeutic Targets Database
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TTD Drug ID: DAP000633

Drug Information
NamePyrimethamine
SynonymsKBio2_003954; MLS002701881; Pyrimethamine (Pyr); CID4993; 2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine; Primethamine; Prestwick_504; MLS002454446; 5-(4-chlorophenyl)-2,4-diamino-6-ethylpyrimidine; KBio2_001386; KBio1_000652; Malocide; GlaxoSmithKline Brand of Pyrimethamine; Pirimetamin; 46706_FLUKA; Daraprim; Spectrum_000906; NSC-3061; 5-(4'-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine; Lactoferrin H & Pyrimethamine; IDI1_000652; UNII-Z3614QOX8W; BW 5063; CCRIS 546; Pirimecidan; Maloprim; WLN: T6N CNJ BZ DZ ER DG& F2; 2,4-Pyrimidinediamine, 5-(p-chlorophenyl)-6-ethyl-; Prestwick0_000037; SPECTRUM1500520; Spectrum5_001447; Lactoferrin B & Pyrimethamine; EXR-101; NSC3061; 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine; S2006_Selleck; WR 2978; Pyrimethamine Hcl; 46706_RIEDEL; CHEMBL36; 4753 R.P.; Pyrimethaminum [INN-Latin]; BRN 0219864; Malocid; Chloridine; NCIOpen2_008313; NCGC00023188-05; NINDS_000652; Spectrum4_000494; Diaminopyritamin; Tindurine; Erbaprelina; TCMDC-125860; CP6; Daraclor; NCGC00023188-04; L000713; AZT + Pyrimethamine combination; Spectrum2_000886; Glaxo Wellcome Brand of Pyrimethamine; NCGC00016256-01; Pyrimidine, 2,4-diamino-5-(p-chlorophenyl)-6-ethyl-; Pirimetamina [Spanish]; 58-14-0; Pyrimethaminum; RP 4753; Pyremethamine; Fansidar (Pyrimethamine/Sulfadoxine); Daraprim (TN); NSC 3061; Chloridyn; KBioGR_001007; NCGC00023188-03; D011739; C07391; Pirimetamina; Malacid; SAM002554921; LS-238; DB00205; BRD-K88429204-001-05-4; BIDD:GT0149; NCGC00016256-02; C12H13ClN4; CD; Daraprin; CPD000058714; Darachlor; 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidi nediamine; BSPBio_003282; 5-(p-chlorophenyl)-6-ethyl-2,4-diaminopyrimidine; nchembio.87-comp22; Prestwick1_000037; Tindurin; Khloridin; DivK1c_000652; Spectrum3_001701; 4753 r.p; KBio3_002502; MLS001148621; KBioSS_001386; AC1L1JDI; KBio2_006522; 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine; SPBio_000672; MolPort-001-783-655; Wellcome Brand of Pyrimethamine; BW 50-63; HMS1568G15; ZINC00057464; AB00052084; D00488; BIDD:PXR0173; nchembio.215-comp13; CAS-58-14-0; SPBio_002054; MLS000028606; Ethylpyrimidine; NCI-C01683; Chloridin; TCMDC-123831; AC-7879; Pyrimethamine (JAN/USP/INN); Aventis Brand of Pyrimethamine; 2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-; HMS2092E13; m alocid; pyrimethamine; CRL-8142 & Pyrimethamine; 5-[4-Chlorophenyl]-6-ethyl-2,4-pyrimidinediamine; Prestwick3_000037; Pyrimethamine [USAN:INN:BAN:JAN]; BPBio1_000147; 2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine; Prestwick2_000037; 5-(4-CHLOROPHENYL)-6-ETHYL-2,4-PYRIMIDINEDIAMINE; NCGC00023188-06; Tinduring; Daraprime; CRL-8131 & Pyrimethamine; NCGC00023188-07; HMS1920N12; Pirimetamina [INN-Spanish]; Pyrimethamin; 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine; BSPBio_000133; NCI60_002604; HMS502A14; EINECS 200-364-2; CHEBI:8673; SMR000058714; AI3-25005; 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE; Darapram
Trade NameDaraprim
IndicationAcute malaria
[ICD9: 084   ICD10: B50-B54]
Approved    [1]
Structure

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InChI1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6
H,2H2,1H3,(H4,14,15,16,17)
InChIKeyWKSAUQYGYAYLPV-UHFFFAOYSA-N
Canonical SMILESCCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl    
Therapeutic ClassAntimalarials
CAS NumberCAS 58-14-0
FormulaC12H13ClN4
PubChem Compound IDCID 4993.
PubChem Substance IDSID 9595.
SuperDrug ATC IDP01BD01
SuperDrug CAS ID000058140;
TargetDihydrofolate reductaseInhibitor[2][3][4]
Ref 1How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30. To Reference
Ref 2Structure of Plasmodium vivax dihydrofolate reductase determined by homology modeling and molecular dynamics refinement. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3257-60. To Reference
Ref 3Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10931-6. To Reference
Ref 4Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum. Mol Biochem Parasitol. 1997 Mar;85(1):25-40. To Reference



 

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