Therapeutic Targets Database
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TTD Drug ID: DAP000635

Drug Information
NameTrimetrexate
SynonymsJB 11; D06238; NCGC00161419-02; TMQ; trimetrexate; 5-methyl-6-({[3,4,5-tris(methyloxy)phenyl]amino}methyl)quinazoline-2,4-diamine; DB01157; CI-898; Trimetrexatum; Trimetrexato; NSC249008; NCGC00161419-01; 2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-; 2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-; Trimetrexate (USAN/INN); NSC-249008; Jb-11; 5-Methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-2,4-quinazolinediamine; C11154; AC1L1KO5; C19H23N5O3; HSDB 6545; BIDD:GT0129; NSC-328564; NSC 249008; Trimetrexatum [INN-Latin]; 6-[((3,4,5-Trimethoxyphenyl)amino)methyl]-5-methyl-2,4-quinazolinediamine; 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine; UNII-UPN4ITI8T4; Trimetrexato [INN-Spanish]; 52128-35-5; CHEMBL119; 2,4-Diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl)quinazoline; CID5583; LS-175340; Trimetrexate [USAN:BAN:INN]
IndicationPneumocystis pneumonia (PCP)
[ICD9: 136.3   ICD10: B20.6]
Approved    [1]
Structure

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InChI1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-
7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24
)
InChIKeyNOYPYLRCIDNJJB-UHFFFAOYSA-N
Canonical SMILESCC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC    
Therapeutic ClassAntifungal Agents
CAS NumberCAS 52128-35-5
FormulaC19H23N5O3
PubChem Compound IDCID 5583.
PubChem Substance IDSID 13336.
SuperDrug ATC IDP01AX07
SuperDrug CAS ID052128355;
TargetDihydrofolate reductaseInhibitor[2][3]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Expression and characterization of recombinant human-derived Pneumocystis carinii dihydrofolate reductase. Antimicrob Agents Chemother. 2000 Nov;44(11):3092-6. To Reference
Ref 3Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases. J Med Chem. 1998 Apr 23;41(9):1409-16. To Reference



 

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