Therapeutic Targets Database
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TTD Drug ID: DAP000652

Drug Information
NameTrovafloxacin
SynonymsAKOS000277872; CHEMBL190562; 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid; AC1L1Y44; CP99219; CHEMBL428; 1,8-Naphthyridine-3-carboxylic acid, 7-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, (1alpha,5alpha,6alpha)-; CP 99,219; DB00685; 7-[(1r,5s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; CP-99,219; C080163; Trovafloxacin; Fluorinated quinolone; C07664; 147059-72-1; 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; TVFX; Trovafloxacin [INN]; C20H15F3N4O3; Trovan (oral); 146836-84-2; Trovafloxacin (INN); LS-95890; CID62959; D08654; 7-((1R,5S)-6-Amino-3-aza-bicyclo[3.1.0]hex-3-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; UNII-9F388J00UK; (1alpha,5alpha,6alpha)-7-(6-Amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; Trovan; CP-99219; 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(6-amino-3-azabicyclo(3.1.0)hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-, (1-alpha,5-alpha,6-alpha)-; CP 99219; AC1Q4NG5
Trade NameTrovan; Turvel
CompanyPfizer Pharmaceuticals
IndicationBacterial infections
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
Approved    [1]
Structure

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InChI1S/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4
-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-
6,24H2,(H,29,30)/t10-,11+,16?
InChIKeyWVPSKSLAZQPAKQ-SOSAQKQKSA-N
Canonical SMILESC1C2C(C2N)CN1C3=C(C=C4C(=O)C(=CN(C4=N3)C5=C(C=C(C=C5)F)F)C(=O)O)F    
Isomeric SMILESC1[C@@H]2[C@@H](C2N)CN1C3=C(C=C4C(=O)C(=CN(C4=N3)C5=C(C=C(C=C5)F)F)C(=O)
O)F
Therapeutic ClassAnti-Infective Agents
CAS NumberCAS 147059-72-1
FormulaC20H15F3N4O3
PubChem Compound IDCID 62959.
PubChem Substance IDSID 9866.
SuperDrug ATC IDJ01MA13
SuperDrug CAS ID147059721;
TargetDNA topoisomerase IIInhibitor[2]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 050762 To Reference
Ref 2Topoisomerase II inhibition involves characteristic chromosomal expression patterns. BMC Genomics. 2008 Jul 8;9:324. To Reference



 

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