Therapeutic Targets Database
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TTD Drug ID: DAP000654

Drug Information
NameNorfloxacin
SynonymsKBio1_000084; D00210; SPECTRUM1500440; HMS1920B16; Norfloxacin [USAN:BAN:INN:JAN]; Oprea1_375152; STK177250; Norfloxacin Merck Brand; AM 715; KBio2_006633; MLS000069650; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid; NCGC00016916-02; BIDD:GT0725; Barazan; ARONIS24170; HMS2091J16; Prestwick0_000221; Spectrum_001017; Prestwick_633; SPBio_002182; HMS2090F03; Prestwick3_000221; D009643; AM-715; CHEMBL9; 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure; S1509_Selleck; MK-366; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[1-piperazinyl]-3-quinoline- carboxylic acid; Chibroxin; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; Spectrum4_000453; HMS1568N03; 70458-96-7; C16H18FN3O3; 3-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-; KBioGR_000866; Sebercim; NCGC00016916-01; KBio3_001607; NCGC00021725-04; AM-0715; AM 0715; SPBio_001173; nchembio820-comp2; Prestwick1_000221; LS-141592; BPBio1_000289; CAS-70458-96-7; Norfloxacino; BSPBio_002107; KBio2_004065; SMR000058200; 68077-27-0; UNII-N0F8P22L1P; Lexinor; MK 0366; Merck Brand of Norfloxacin; Norfloxacinum [INN-Latin]; DivK1c_000084; DB01059; BRN 0567897; NCGC00021725-03; KBioSS_001497; BCBcMAP01_000218; Prestwick2_000221; BB_SC-0063; Noroxin (TN); norfloxacin; Spectrum2_001017; BSPBio_000261; Noroxin; Chibroxin, MK-366, Baccidal, Sebercim, Zoroxin, Norfloxacin; Norflo; Norfloxacinum; MK 366; 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-; Norfloxacin (JP15/USP/INN); AC1L1IE1; I14-0947; CCRIS 6302; AKOS000417391; MolPort-001-738-625; 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; EINECS 274-614-4; Norfloxacino [INN-Spanish]; NFLX; Norfloxacine [INN-French]; BRD-K11196887-001-05-5; MK0366; C06687; CHEBI:100246; MK366; KBio2_001497; Spectrum3_000524; NINDS_000084; Norfloxacine; 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid; Fulgram; SMP1_000216; Baccidal; Spectrum5_001154; HMS500E06; CID4539; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid; AM0715; IDI1_000084; MK-0366; AC-6855
Trade NameApo-Norflox; Chibroxin; Floxin; Insensye; Norflohexal; Noroxin; Norfocin; Nufloxib; Roxin; Utin; Utinor
IndicationBacterial infections
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
Approved    [1]
Structure

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InChI1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)
19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
InChIKeyOGJPXUAPXNRGGI-UHFFFAOYSA-N
Canonical SMILESCCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O    
Therapeutic ClassAnti-Bacterial Agents
CAS NumberCAS 70458-96-7
FormulaC16H18FN3O3
PubChem Compound IDCID 4539.
PubChem Substance IDSID 8912.
SuperDrug ATC IDJ01MA06; S01AE02
SuperDrug CAS ID070458967;
TargetDNA topoisomerase IIInhibitor[2][3]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074690 To Reference
Ref 2Gametocytocidal activity of pyronaridine and DNA topoisomerase II inhibitors against multidrug-resistant Plasmodium falciparum in vitro. Parasitol Int. 2000 Feb;48(4):275-80. To Reference
Ref 3Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrob Agents Chemother. 1988 Aug;32(8):1182-6. To Reference



 

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