Therapeutic Targets Database
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TTD Drug ID: DAP000655

Drug Information
NameOfloxacin
SynonymsFloxin (TN); BPBio1_000345; Prestwick3_000237; 33703_FLUKA; Oflocee; SPBio_001387; Floxstat; Inoflox; Praxin; 83380-47-6; HMS1921H12; KBio2_006802; 85344-55-4; KBio1_000721; Exocine; Ofloxacine; MLS000028749; ORF 18489; DEXTROFLOXACINE; Otonil; O-Flox; PT 01; Tabrin; Loxinter; Ofloxacin, (S)-Isomer; ( -)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazin-6-carbonsaeure; MolPort-000-873-068; ORF-28489; SAM002264629; Medofloxine; NCGC00094219-05; NCGC00178284-02; Onexacin; DL-8280, HOE-280, Exocin, Flobacin, Floxin, Floxil, Monoflocet, Ofloxacin; Ofloxacino; Quotavil; Lopac0_000904; Oxaldin; SPBio_002234; S1463_Selleck; Sinflo; KBio3_002617; Ofloxacina; HMS2090F07; DivK1c_000721; HMS502E03; Hoe-280; Visiren; Rilox; STK256723; NCGC00178284-01; NCGC00094219-02; MLS001074203; Quinolon; 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (+-)-; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- -oxo-7H-pyrido(1,2,3-de)- -1,4-benzoxazine-6-carboxylic acid; Oflodura; Novecin; Fugacin; OFX; Ru-43280; Operan; EU-0100904; Ofloxacin Otic; Ofus; C07321; KBio2_004234; 82419-36-1; Ofloxacine [French]; Marfloxacin; KBio2_001666; UNII-A4P49JAZ9H; Orocin; (+-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; Prestwick2_000237; Floxil; AKOS001033517; NCGC00094219-04; Obide; DL-8280; Kinoxacin; Prestwick0_000237; Oflodal; Qinolon; D00453; Liflox; FLOXIN IN DEXTROSE 5% IN PLASTIC CONTAINER; Zanocin; CHEBI:7731; Uro Tarivid; BRD-A24228527-001-05-9; Ofloxacinum [Latin]; SPECTRUM1502044; 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (+-)-; Oflin; Flotavid; Oflocet; BSPBio_000313; Effexin; HOE 280; C18H20FN3O4; XED; ofloxacin; MolPort-000-422-241; AC-7616; Ofloxacine; DL-8280; HOE-280; 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; IDI1_000721; Ofcin; Oflox; O 8757; NCGC00094219-03; CID4583; Mergexin; O8757_SIGMA; WP-0405; (+/-)-Floxin; Viotisone; AB00513820; Pharflox; CCRIS 5233; NCGC00015772-10; Floxin otic; 118120-51-7 (hydrochloride); Danoflox; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperaz inyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; Ofloxin; I06-0112; Oflocin; Spectrum_001186; Taravid; Prestwick1_000237; FLOXIN IN DEXTROSE 5%; Qipro; SMR000058192; Floxal; Flobacin; KBioSS_001666; KBioGR_000667; Oprea1_242882; DL 8280; Spectrum4_000324; Flodemex; Nufafloqo; DB01165; HMS1568P15; Exocin; I06-0380; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; Floxin; 33703_RIEDEL; Spectrum5_001063; 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-; NSC727071; NCGC00015772-02; Ofloxacina [DCIT]; AC1L1IHM; Puiritol; Oflodex; Flovid; LS-133259; Telbit; OFLX; HMS2092B10; Ofloxacin (JP15/USP/INN); NCGC00094219-06; BSPBio_003117; Spectrum2_001464; Ofloxacin [USAN:BAN:INN:JAN]; Ofloxacino [Spanish]; Bactocin; BB_SC-1252; Ocuflox; CPD000058192; Kinflocin; Tructum; Tariflox; Spectrum3_001499; BRN 3657947; Occidal; NCGC00094219-01; Ofloxacinum; Tarivid; CHEMBL4; NINDS_000721
Trade NameOcuflox; Floxin Otic; Marfloxacin
CompanyJanssen Pharmaceutica
IndicationBacterial infections
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
Approved    [1]
Structure

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InChI1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7
-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
InChIKeyGSDSWSVVBLHKDQ-UHFFFAOYSA-N
Canonical SMILESCC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O    
Therapeutic ClassAnti-Bacterial Agents
CAS NumberCAS 82419-36-1
FormulaC18H20FN3O4
PubChem Compound IDCID 4583.
PubChem Substance IDSID 9529.
SuperDrug ATC IDJ01MA01; S01AE01; S02AA16
SuperDrug CAS ID082419361;
TargetDNA topoisomerase IIInhibitor[2]
Ref 1Emerging therapies for the treatment and prevention of otitis media. Expert Opin Emerg Drugs. 2006 May;11(2):251-64. To Reference
Ref 2Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrob Agents Chemother. 1988 Aug;32(8):1182-6. To Reference



 

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