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TTD Drug ID: DAP000676

Drug Information
NamePicrotoxin
SynonymsNSC 403139; CID6473767; Indian berry; Caswell No. 663A; P1675_SIGMA; AC1L1LDB; Picrotin, compd. with picrotoxinin (1:1); Picrotin - Picrotoxinin; Sesquiterpene; PICROTOXIN; Lopac0_000916; AC1LAQW2; 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6; NCGC00094227-01; Picrotoxinum; SAM001246993; CPD000469289; )-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione (1:1); 124-87-8; NSC403139; Oriental berry; Picrotoxin (Compound of one mole Picrotoxinin and one mole Picrotin); Cocculin; MLS001423995; AI3-17689; Coques du levant [French]; SMR000469289; 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione (1:1); HSDB 6385; Picrotin, compound with picrotoxinin (1:1); Ambap124-87-8; EU-0100916; CID518601; C15H16O6.C15H18O7; MolPort-003-800-101; Picrotoxine; Picrotoxinin, compd. with picrotin (1:1); HMS2051E09; CID31304; 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione; 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)- & (1aR,2aR,3S,6R,6aS,8aS,8bR,9R; CHEMBL506977; MolPort-003-894-698; Cocculus; LS-109760; EINECS 204-716-6; Fish berry; EPA Pesticide Chemical Code 002301; P 1675; Coques du levant; 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-, compd. with (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione (1:1); 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, [1aR-(1a.alpha.,2; Picrotoxinin - picrotin; 80410_FLUKA; Picrotox; DB00466
IndicationRespiratory distress
[ICD9: 518.5, 518.82   ICD10: J80]
Approved    [1]
Structure

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InChI1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4
-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4
-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-
3H3
InChIKeyVJKUPQSHOVKBCO-UHFFFAOYSA-N
Canonical SMILESCC(=C)C1C2C3C4(C(C1C(=O)O2)(CC5C4(O5)C(=O)O3)O)C.CC12C3C4C(C(C1(CC5C2
(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O    
Therapeutic ClassCentral Nervous System Stimulants
CAS NumberCAS 124-87-8
FormulaC30H34O13
PubChem Compound IDCID 518601.
PubChem Substance IDSID 8670198.
TargetGamma-aminobutyric acid receptor subunit alpha-1Antagonist[2]
Ref 1Drug information of Picrotoxin, 2008 To Reference
Ref 2DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29. To Reference



 

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