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TTD Drug ID: DAP000716

Drug Information
NameMivacurium
SynonymsMivacurii chloridum; bis[3-[(1R)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] (E)-oct-4-enedioate dichloride; Mivacurium; 133814-19-4; MIVACURIUM CHLORIDE; Mivacurium chloride (USAN/INN); (R)-1,2,3,4-Tetrahydro-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, (E)-4-octenedioate (2:1); Mivacurii chloridum [Latin]; Mivacron; Chlorure de mivacurium [French]; Cloruro de mivacurio [Spanish]; MIVACRON IN DEXTROSE 5% IN PLASTIC CONTAINER; C58H80N2O14; BW B109OU dichloride; AC1NQXZZ; NCGC00167469-01; LS-172022; 106861-44-3; C07550; CID5281042; Mivacron (TN); CHEMBL984; D00763; BWB109OU; BW-B109OU; BW-B1090U; Cloruro de mivacurio; bis[3-[(1R)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] (E)-oct-4-enedioate; DB01226; Mivacurium chloride [USAN:INN:BAN]; Chlorure de mivacurium; Isoquinolinium, 2,2'-((1,8-dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl))bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-((3,4,5-trimethoxyphenyl)methyl)-, dichloride, (R-(R*,R*-(E)))-; Isoquinolinium, 2,2'-((1,8-dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl))bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-((3,4,5-trimethoxyphenyl)methyl)-, (1R-(1R*(E(1'R*))))-; 106791-40-6; AC1NQXXZ; CID5281080
IndicationGeneral anesthesia
[ICD9: 338   ICD10: R52]
Approved    [1]
Structure

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InChI1S/C58H80N2O14/c1-59(25-21-41-35-47(63-3)49(65-5)37-43(41)45(59)2
9-39-31-51(67-7)57(71-11)52(32-39)68-8)23-17-27-73-55(61)19-15-13
-14-16-20-56(62)74-28-18-24-60(2)26-22-42-36-48(64-4)50(66-6)38-4
4(42)46(60)30-40-33-53(69-9)58(72-12)54(34-40)70-10/h13-14,31-38,
45-46H,15-30H2,1-12H3/q+2/b14-13+/t45-,46-,59?,60?/m1/s1
InChIKeyILVYCEVXHALBSC-OTBYEXOQSA-N
Canonical SMILESC[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C(=C3)OC)OC)OC)OC)OC)CCCOC(=O)CCC=CCCC
(=O)OCCC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C(=C6)OC)OC)OC)OC)OC)C    
Isomeric SMILESC[N+]1(CCC2=CC(=C(C=C2[C@H]1CC3=CC(=C(C(=C3)OC)OC)OC)OC)OC)CCCOC(=O)CC/
C=C/CCC(=O)OCCC[N+]4(CCC5=CC(=C(C=C5[C@H]4CC6=CC(=C(C(=C6)OC)OC)OC)OC)
OC)C
Therapeutic ClassNeuromuscular Nondepolarizing Agents
CAS NumberCAS 106791-40-6
FormulaC58H80N2O14
PubChem Compound IDCID 5281042.
PubChem Substance IDSID 9753.
SuperDrug ATC IDM03AC10
SuperDrug CAS ID106861443;
TargetNeuronal acetylcholine receptor subunit alpha-2Antagonist[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. To Reference



 

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