Therapeutic Targets Database
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TTD Drug ID: DAP000745

Drug Information
NameTorasemide
SynonymsAC1L26H7; 3-pyridinesulfonamide,N-(((1-methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-; MLS001424121; CAS-56211-40-6; Luprac; MLS001195611; PW-2132; KBio2_002256; Prestwick2_001030; Torasemide N; SPBio_003080; N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide; Spectrum5_001699; Luprac (TN); BRN 0498515; MolPort-002-885-870; JDL 464; AC1Q6UVM; KBioGR_000820; 3-Pyridinesulfonamide, N-(((1-methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-; Torocard; Torsemide [USAN]; 1-isopropyl-3-[(4- m -toluidino-3-pyridyl) sulfonyl]urea; Ambap56211-40-6; KBio3_003008; BIDD:GT0623; Unat; C16H20N4O3S; Spectrum4_000290; Demadex, Torsemide; NCGC00095141-01; TL8003646; Dilutol; Spectrum3_001832; AC 4464; 1-isopropyl-3-((4-(3-methylphenylamino)pyridine)-3-sulfonyl)urea; Sutril; CID41781; BM 02015; MolPort-003-666-610; ZINC00005823; 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea; AC-4464; HMS1922N05; KS-1123; 1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea; AB00514011; Torasemidum; JDL-464; GJ-1090; C026116; Toradiur; 56211-40-6; NCGC00016879-01; LS-131973; BPBio1_001341; SMR000466313; Torasemide; NCGC00095141-03; Prestwick0_001030; N-{[(1-methylethyl)amino]carbonyl}-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide; Torasemida; Spectrum_001776; Prestwick1_001030; SAM001246567; BSPBio_003503; Torasemida [INN-Spanish]; Torsemide (USP); Torem; TORSEMIDE; UNII-W31X2H97FB; BSPBio_001219; Presoril; HMS2051L21; Torasemidum [INN-Latin]; Prestwick3_001030; NCGC00095141-02; Demadex (TN); I06-0056; AC-18762; SPBio_001063; BM-02015; DB00214; N-(Isopropylcarbamoyl)-4-(m-tolylamino)pyridine-3-sulfonamide; CHEMBL1148; CCRIS 6736; KBio2_004824; S1698_Selleck; BRD-K30480208-001-05-2; Spectrum2_001142; KBio2_007392; Torasemide (JAN/INN); Torrem; SPECTRUM1505211; KBioSS_002257; Demadex; D00382; MLS000759418; HMS1571M21; CPD000466313; MLS001165687
Trade NameDemadex
IndicationEdema associated with congestive heart failure
[ICD9: 428.0, 782.3   ICD10: I50, R60.9]
Approved    [1]
Structure

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InChI1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19
-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
InChIKeyNGBFQHCMQULJNZ-UHFFFAOYSA-N
Canonical SMILESCC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C    
Therapeutic ClassDiuretics
CAS NumberCAS 56211-40-6
FormulaC16H20N4O3S
PubChem Compound IDCID 41781.
PubChem Substance IDSID 182449.
SuperDrug ATC IDC03CA04
SuperDrug CAS ID056211406;
TargetSolute carrier family 12 member 1Blocker[2][3][4]
Ref 1Drug information of Torasemide, 2008 To Reference
Ref 2Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs. Clin Pharmacol Ther. 2007 Sep;82(3):300-9. Epub 2007 Apr 25. To Reference
Ref 3Effects of loop diuretics on angiotensin II-stimulated vascular smooth muscle cell growth. Nephrol Dial Transplant. 2001;16 Suppl 1:14-7. To Reference
Ref 4Hypertension. 1999 Jul;34(1):138-43.Torasemide inhibits angiotensin II-induced vasoconstriction and intracellular calcium increase in the aorta of spontaneously hypertensive rats. To Reference



 

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