Therapeutic Targets Database
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TTD Drug ID: DAP000760

Drug Information
NameTrifluridine
SynonymsMLS000028361; Viroptic, Trifluorothymidine, Trifluridine; MLS001148248; 2'-Deoxy-5-trifluoromethyluridine; CHEMBL1129; 2'-Deoxy-5-(trifluoromethyl)uridine; NSC 529182; C10H11F3N2O5; 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione; 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-ribofuranosyl)-5-(trifluoromethyl)-; F3T; 5-Trifluoro-2'-deoxythymidine; Trifluridinum; TFDU; F3TDR; CID6256; NSC529182; Trifluoromethyldeoxyuridine; D00391; ZINC03842753; UNII-RMW9V5RW38; Thymidine, alpha,alpha,alpha-trifluoro-; Uridine, 2'-deoxy-5-(trifluoromethyl)-; CHEBI:269321; Viroptic; SMR000058583; BRN 0568095; S1778_Selleck; Trifluridine (USP/INN); T2511; T2255_SIGMA; Fluridine; Virophta; LS-153788; Trifluridine [USAN:INN]; AC1L1M4O; Trifluoridine; Trifluridina; CF3dUrd; CCRIS 2348; Uridine, 2'-deoxy-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2'-deoxyuridine; NSC75520; 5-(Trifluoromethyl)deoxyuridine; Trifluorothymine deoxyriboside; 5-Trifluoromethyl-2-deoxyuridine; Trifluridine; alpha,alpha,alpha-Trifluorothymidine; FT-0082240; 5-Trifluoromethyl-2'-deoxyuridine; HS-0007; Viroptic (TN); TRIFLUOROTHYMIDINE; 5-Trifluorothymidine; Trifluridina [INN-Spanish]; EINECS 200-722-8; 70-00-8; Trifluridinum [INN-Latin]; F3DThd; DB00432; NSC 75520
Trade NameViroptic
CompanyMonarch Pharmaceuticals
IndicationViral Infection
[ICD9: 042-075   ICD10: A80-A99, B00-B34]
Approved    [1]
Structure

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InChI1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-1
6)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
InChIKeyVSQQQLOSPVPRAZ-RRKCRQDMSA-N
Canonical SMILESC1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O    
Isomeric SMILESC1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O
Therapeutic ClassAntiviral Agents
CAS NumberCAS 70-00-8
FormulaC10H11F3N2O5
PubChem Compound IDCID 6256.
PubChem Substance IDSID 149181.
SuperDrug ATC IDS01AD02
SuperDrug CAS ID000070008;
TargetThymidylate synthaseInhibitor[2]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074311 To Reference
Ref 2Trifluorothymidine induces cell death independently of p53. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):699-703. To Reference



 

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