Therapeutic Targets Database
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TTD Drug ID: DAP000783

Drug Information
NameMycophenolate mofetil
SynonymsCHEMBL1456; TM-MMF; NCGC00159459-02; C23H31NO7; MMF CellCept(TM); Munoloc; Mycophenolate mofetil (JAN/USAN); o-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (E)-; ME-MPA; NCGC00159459-03; 2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate; S1501_Selleck; 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (E)-; C07908; Mycophenylate mofetil; 128794-94-5; CellCept; I01-0898; AR-1J6939; LS-75572; 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)-; 2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate; RS 61443; 140401-05-4; Cellcept (TN); RS-61443; RS-61443-190; AC1NQXZW; AC1Q6O6X; 2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate; 115007-34-6; HSDB 7436; Mycophenolic acid morpholinoethyl ester; BB_NC-2566; LS-172272; 2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate; mycophenolate mofetil; CellCept, RS 61443, TM-MMF, Mycophenolate mofetil; UNII-9242ECW6R0; 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E); CID5281078; I06-1947; R-99; MMF; TL8000648; DB00688; HMS2090A03; AC-1562; MolPort-000-883-800; NSC724229; ZINC21297660; D00752
Trade NameCellCept
CompanyRoche
IndicationOrgan transplant rejection
[ICD9: 279.5, 996   ICD10: D89.8, T86]
Approved    [1]
Pemphigus vulgaris
[ICD9: 694.4   ICD10: L10.0]
Phase III    [1]
Structure

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InChI1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-2
1(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15
-4+
InChIKeyRTGDFNSFWBGLEC-SYZQJQIISA-N
Canonical SMILESCC1=C(C(=C(C2=C1COC2=O)O)CC=C(C)CCC(=O)OCCN3CCOCC3)OC    
Isomeric SMILESCC1=C(C(=C(C2=C1COC2=O)O)C/C=C(\C)/CCC(=O)OCCN3CCOCC3)OC
Therapeutic ClassImmunosuppressive Agents
CAS NumberCAS 128794-94-5
FormulaC23H31NO7
PubChem Compound IDCID 5281078.
PubChem Substance IDSID 10110.
SuperDrug ATC IDL04AA06
L04AA06
TargetInosine-5'-monophosphate dehydrogenase 2Inhibitor[2]
Inosine-5'-monophosphate dehydrogenase 2Inhibitor[3][4]
Ref 1Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54. To Reference
Ref 2Roche. Product Development Pipeline. July 29 2009. To Reference
Ref 3Clin Chem. 2009 May;55(5):986-93. Epub 2009 Mar 19.Effect of mycophenolate acyl-glucuronide on human recombinant type 2 inosine monophosphate dehydrogenase. To Reference
Ref 4Nat Rev Drug Discov. 2003 Jan;2(1):38-51.Knockouts model the 100 best-selling drugs--will they model the next 100? To Reference



 

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