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TTD Drug ID: DAP000793

Drug Information
NameToremifene
SynonymsEthanamine, 2-(4-((1Z)-4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-; BIDD:ER0222; 2-({4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenyl}oxy)-N,N-dimethylethanamine; NCGC00160530-01; CHEMBL1655; C08166; D08620; 98644-21-4; BIDD:GT0211; CHEBI:9635; GTx-006; STK626445; (Z)-2-(4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine; Z-Toremifene; 89778-27-8 (citrate (1:1)); Toremifene Citrate (1:1); GTx 006; {2-[4-(4-Chloro-1,2-diphenyl-but-1-enyl)-phenoxy]-ethyl}-dimethyl-amine; CCRIS 8745; Farestone; 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine; toremifene; Ethanamine, 2-(4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; CID3005573; GTX-006 (Acapodene); Toremifeno; 2-(p-[(Z)-4-chloro-1,2-diphenyl-1-butenyl]-phenoxy)-N,N-dimethyl-ethylamine citrate(1:1); Toremifeno [Spanish]; AC-1751; Estrimex; STOCK6S-27411; DB00539; FC-1157a; HMS2090B22; Toremifenum; 2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine; UNII-7NFE54O27T; AC1MHJ33; 89778-26-7; 2-(para-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine (IUPAC); LS-7729; Toremifenum [Latin]; MolPort-002-508-208; BIDD:PXR0202; Acapodene; Toremifene Base; Toremifene [INN:BAN]; Toremifene (INN)
Trade NameFareston; Acapodene
CompanyGTx, Inc
IndicationBreast CancerApproved    [1]
Structure

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InChI1S/C26H28ClNO/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-
8-12-22)25(17-18-27)21-9-5-3-6-10-21/h3-16H,17-20H2,1-2H3/b26-25-
InChIKeyXFCLJVABOIYOMF-QPLCGJKRSA-N
Canonical SMILESCN(C)CCOC1=CC=C(C=C1)C(=C(CCCl)C2=CC=CC=C2)C3=CC=CC=C3    
Isomeric SMILESCN(C)CCOC1=CC=C(C=C1)/C(=C(/CCCl)\C2=CC=CC=C2)/C3=CC=CC=C3
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 89778-26-7
FormulaC26H28ClNO
PubChem Compound IDCID 3005573.
PubChem Substance IDSID 10366.
ChEBI9635;
SuperDrug ATC IDL02BA02
SuperDrug CAS ID089778267;
TargetEstrogen receptorModulator[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Effect of selective estrogen receptor modulators on cell proliferation and estrogen receptor activities in normal human prostate stromal and epithelial cells. Prostate Cancer Prostatic Dis. 2009 May 26. [Epub ahead of print] To Reference



 

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