Therapeutic Targets Database
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TTD Drug ID: DAP000795

Drug Information
NameMeclizine
SynonymsRu-Vert-M; Antivert; KBioGR_000473; 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine; Itinerol; KBio1_000407; KBioSS_001371; Antivert/50; 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine; 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine; KBio3_001449; NINDS_000407; UNII-3L5TQ84570; BSPBio_000534; IDI1_000407; KBio2_003939; EINECS 209-323-3; Postafene; Sea-Legs; NSC169189; Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-; Spectrum_000891; DB00737; (+-)-Meclizine; Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-; HSDB 3113; Parachloramine; D08163; 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine; meclizine; 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine; Suprimal; Nevidoxine (TN); Prestwick3_000457; AB00053493; Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-; 1-(p-Chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)piperazine; SPBio_002473; C07116; Histamethizine; Marex; Spectrum2_000110; Histametizyne; Dramamine II; Diadril; Meclizine Hcl; UCB 5062; KBio2_006507; Antivert/25; Neo-suprimel; U. C. B. 5062; Meclicot; Meclozina [INN-Spanish]; WLN: T6N DNTJ AYR&R DG& D1R C1; Nevidoxine; Histametizyn; Travelon; Ancolon; Spectrum4_000037; Prestwick2_000457; 36236-67-6 (hydrochloride); 1-p-Chlorobenzhydryl-4-m-methylbenzylpiperazine; Sabari; DivK1c_000407; SPBio_000100; BPBio1_000588; Bonadettes; Siguran; Navicalm; Vomissels; Monamine; CID4034; Calmonal; LS-111206; BSPBio_001949; BRN 0332002; Ravelon; NSC 169189; AC1L1H9K; Prestwick1_000457; L001136; Ancolan; Vomisseis; U.C.B. 5062; 1-((4-Chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)piperazine; 569-65-3; CHEMBL1623; C25H27ClN2; Neo-suprimal; UCB 5052; Neo-istafene; Meclozinum [INN-Latin]; Peremesin; AC1Q2IO5; Meclozina; Subari; Veritab; Meclozinum; Histamethine; Chiclida; UCB 170; Medivert; Meclizine [INN:BAN]; MolPort-002-069-043; Bonine; KBio2_001371; Piperazine, 1-(p-chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)-; Histametizine; Spectrum5_000919; 1104-22-9 (di-hydrochloride); Meclozine; Spectrum3_000485; Prestwick0_000457; Meclozine (BAN); BRD-A50311610-300-05-4
Trade NameBonine; Bonamine; Antivert; Postafen; Dramamine
IndicationNausea and vomiting
[ICD9: 787, 787.0   ICD10: R11]
Approved    [1]
Structure

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InChI1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-
8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3
InChIKeyOCJYIGYOJCODJL-UHFFFAOYSA-N
Canonical SMILESCC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl    
Therapeutic ClassAnti-Allergic Agents
CAS NumberCAS 569-65-3
FormulaC25H27ClN2
PubChem Compound IDCID 4034.
PubChem Substance IDSID 9327.
SuperDrug ATC IDR06AE05
SuperDrug CAS ID000569653;
TargetOrphan nuclear receptor NR1I3Modulator[2]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 010721 To Reference
Ref 2Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Drug Metab Rev. 2006;38(1-2):51-73. To Reference



 

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