Therapeutic Targets Database
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TTD Drug ID: DAP000802

Drug Information
NameInsulin recombinant
IndicationDiabetes mellitus
[ICD9: 250   ICD10: E08-E13]
Approved    [1]
Structure

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InChI1S/C256H381N65O77S6/c1-29-130(23)202(311-190(337)103-258)250(391)
315-200(128(19)20)246(387)286-158(75-82-197(347)348)216(357)281-1
54(70-77-186(261)333)220(361)306-181-115-402-403-116-182-241(382)
303-176(110-323)238(379)293-161(88-122(7)8)224(365)294-167(95-139
-53-61-145(328)62-54-139)227(368)282-153(69-76-185(260)332)217(35
8)289-160(87-121(5)6)222(363)283-157(74-81-196(345)346)219(360)30
1-173(101-188(263)335)233(374)297-169(97-141-57-65-147(330)66-58-
141)230(371)307-180(240(381)302-174(254(395)396)102-189(264)336)1
14-401-400-113-179(213(354)272-106-191(338)277-152(72-79-194(341)
342)215(356)280-150(51-42-84-270-256(266)267)211(352)271-107-192(
339)278-165(93-137-46-36-32-37-47-137)226(367)296-166(94-138-48-3
8-33-39-49-138)229(370)298-170(98-142-59-67-148(331)68-60-142)236
(377)318-205(134(27)326)253(394)321-85-43-52-184(321)244(385)284-
151(50-40-41-83-257)221(362)319-206(135(28)327)255(397)398)309-24
7(388)199(127(17)18)314-234(375)163(90-124(11)12)291-228(369)168(
96-140-55-63-146(329)64-56-140)295-223(364)159(86-120(3)4)288-209
(350)132(25)276-214(355)156(73-80-195(343)344)285-245(386)198(126
(15)16)313-235(376)164(91-125(13)14)292-232(373)172(100-144-105-2
69-119-275-144)300-237(378)175(109-322)279-193(340)108-273-212(35
3)178(112-399-404-117-183(308-242(181)383)243(384)317-204(133(26)
325)251(392)304-177(111-324)239(380)316-203(131(24)30-2)249(390)3
10-182)305-225(366)162(89-123(9)10)290-231(372)171(99-143-104-268
-118-274-143)299-218(359)155(71-78-187(262)334)287-252(393)207(20
8(265)349)320-248(389)201(129(21)22)312-210(351)149(259)92-136-44
-34-31-35-45-136/h31-39,44-49,53-68,104-105,118-135,149-184,198-2
07,322-331H,29-30,40-43,50-52,69-103,106-117,257-259H2,1-28H3,(H2
,260,332)(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,
349)(H,268,274)(H,269,275)(H,271,352)(H,272,354)(H,273,353)(H,276
,355)(H,277,338)(H,278,339)(H,279,340)(H,280,356)(H,281,357)(H,28
2,368)(H,283,363)(H,284,385)(H,285,386)(H,286,387)(H,287,393)(H,2
88,350)(H,289,358)(H,290,372)(H,291,369)(H,292,373)(H,293,379)(H,
294,365)(H,295,364)(H,296,367)(H,297,374)(H,298,370)(H,299,359)(H
,300,378)(H,301,360)(H,302,381)(H,303,382)(H,304,392)(H,305,366)(
H,306,361)(H,307,371)(H,308,383)(H,309,388)(H,310,390)(H,311,337)
(H,312,351)(H,313,376)(H,314,375)(H,315,391)(H,316,380)(H,317,384
)(H,318,377)(H,319,362)(H,320,389)(H,341,342)(H,343,344)(H,345,34
6)(H,347,348)(H,395,396)(H,397,398)(H4,266,267,270)/t130-,131-,13
2+,133+,134+,135+,149+,150+,151+,152+,153+,154+,155+,156+,157+,15
8+,159+,160+,161+,162+,163+,164+,165+,166+,167+,168+,169+,170+,17
1+,172+,173+,174+,175+,176+,177+,178+,179+,180+,181+,182-,183+,18
4+,198+,199+,200+,201+,202+,203+,204+,205+,206+,207+/m1/s1
InChIKeyYAJCHEVQCOHZDC-QMMNLEPNSA-N
Canonical SMILESCCC(C)C1C(=O)NC2CSSCC(C(=O)NC(CSSCC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)
NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)C
(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)CC(C)
C)CC3=CC=C(C=C3)O)CCC(=O)N)CC(C)C)CCC(=O)O)CC(=O)N)CC4=CC=C(C=C4)O)C(=O)
NC(CC(=O)N)C(=O)O)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=
O)NC(CC5=CC=CC=C5)C(=O)NC(CC6=CC=CC=C6)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(C
(C)O)C(=O)N8CCCC8C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)O)C(C)C)CC(C)C)CC9=CC=
C(C=C9)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)C)CC2=CNC=N2)CO)NC(=O)C(CC(C)C)NC
(=O)C(CC2=CNC=N2)NC(=O)C(CCC(=O)N)NC(=O)C(C(=O)N)NC(=O)C(C(C)C)NC(=O)C
(CC2=CC=CC=C2)N)C(=O)NC(C(=O)NC(C(=O)N1)CO)C(C)O)NC(=O)C(CCC(=O)N)NC(=O)
C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(C(C)CC)NC(=O)CN    
Isomeric SMILESCC[C@@H](C)[C@H]1C(=O)N[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)
NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@
H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@
H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=
O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CO)CC(C)C)CC3=CC=C(C=C3)O)CCC(=
O)N)CC(C)C)CCC(=O)O)CC(=O)N)CC4=CC=C(C=C4)O)C(=O)N[C@@H](CC(=O)N)C(=O)O)
C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H]
(CC5=CC=CC=C5)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=
O)N[C@@H]([C@H](C)O)C(=O)N8CCC[C@H]8C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@
H](C)O)C(=O)O)C(C)C)CC(C)C)CC9=CC=C(C=C9)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)
C)CC2=CNC=N2)CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H]
(CCC(=O)N)NC(=O)[C@H](C(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC2=CC=CC=C2)
N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CO)[C@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=
O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]([C@H](C)CC)NC(=O)CN
Therapeutic ClassHypoglycemic Agents
CAS NumberCAS 9004-10-8
FormulaC257H387N65O76S6
PubChem Compound IDCID 70678557.
TargetInsulin receptorBinder[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Nat Rev Drug Discov. 2003 Jan;2(1):38-51.Knockouts model the 100 best-selling drugs--will they model the next 100? To Reference



 

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