Therapeutic Targets Database
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TTD Drug ID: DAP000822

Drug Information
NameInsulin-lispro
Trade NameHumalog
CompanyEli Lilly and Company
IndicationDiabetes mellitus
[ICD9: 250   ICD10: E08-E13]
Approved    [1]
Structure

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InChI1S/C158H234N40O42S2.C99H155N25O35S4/c1-79(2)57-104(181-131(213)86
(15)173-136(218)102(50-53-125(211)212)179-152(234)127(84(11)12)19
4-148(230)107(60-82(7)8)184-145(227)113(67-95-70-166-78-172-95)18
9-150(232)115(74-199)176-123(208)73-170-134(216)116(75-241)191-14
0(222)105(58-80(3)4)182-144(226)112(66-94-69-165-77-171-94)188-13
8(220)101(48-51-119(161)204)178-146(228)114(68-120(162)205)190-15
3(235)126(83(9)10)193-132(214)98(160)61-89-31-21-18-22-32-89)139(
221)185-110(64-92-40-44-96(202)45-41-92)142(224)183-106(59-81(5)6
)147(229)195-128(85(13)14)154(236)192-117(76-242)135(217)169-71-1
21(206)174-100(49-52-124(209)210)137(219)177-99(38-29-55-167-158(
163)164)133(215)168-72-122(207)175-108(62-90-33-23-19-24-34-90)14
1(223)186-109(63-91-35-25-20-26-36-91)143(225)187-111(65-93-42-46
-97(203)47-43-93)149(231)196-129(87(16)200)155(237)180-103(37-27-
28-54-159)156(238)198-56-30-39-118(198)151(233)197-130(88(17)201)
157(239)240;1-12-46(9)77(121-73(134)36-100)97(156)122-76(45(7)8)9
5(154)108-56(25-29-75(137)138)80(139)105-54(23-27-70(102)131)83(1
42)117-66(40-161)93(152)119-68(42-163)94(153)124-79(48(11)127)98(
157)116-64(38-126)90(149)123-78(47(10)13-2)96(155)120-67(41-162)9
2(151)115-63(37-125)89(148)110-58(31-44(5)6)85(144)111-59(32-49-1
4-18-51(128)19-15-49)86(145)106-53(22-26-69(101)130)81(140)109-57
(30-43(3)4)84(143)107-55(24-28-74(135)136)82(141)113-61(34-71(103
)132)88(147)112-60(33-50-16-20-52(129)21-17-50)87(146)118-65(39-1
60)91(150)114-62(99(158)159)35-72(104)133/h18-26,31-36,40-47,69-7
0,77-88,98-118,126-130,199-203,241-242H,27-30,37-39,48-68,71-76,1
59-160H2,1-17H3,(H2,161,204)(H2,162,205)(H,165,171)(H,166,172)(H,
168,215)(H,169,217)(H,170,216)(H,173,218)(H,174,206)(H,175,207)(H
,176,208)(H,177,219)(H,178,228)(H,179,234)(H,180,237)(H,181,213)(
H,182,226)(H,183,224)(H,184,227)(H,185,221)(H,186,223)(H,187,225)
(H,188,220)(H,189,232)(H,190,235)(H,191,222)(H,192,236)(H,193,214
)(H,194,230)(H,195,229)(H,196,231)(H,197,233)(H,209,210)(H,211,21
2)(H,239,240)(H4,163,164,167);14-21,43-48,53-68,76-79,125-129,160
-163H,12-13,22-42,100H2,1-11H3,(H2,101,130)(H2,102,131)(H2,103,13
2)(H2,104,133)(H,105,139)(H,106,145)(H,107,143)(H,108,154)(H,109,
140)(H,110,148)(H,111,144)(H,112,147)(H,113,141)(H,114,150)(H,115
,151)(H,116,157)(H,117,142)(H,118,146)(H,119,152)(H,120,155)(H,12
1,134)(H,122,156)(H,123,149)(H,124,153)(H,135,136)(H,137,138)(H,1
58,159)/t86-,87+,88+,98-,99-,100-,101-,102-,103-,104-,105-,106-,1
07-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,126-,1
27-,128-,129-,130-;46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61
-,62-,63-,64-,65-,66-,67-,68-,76-,77-,78-,79-/m00/s1
InChIKeyWNRQPCUGRUFHED-DETKDSODSA-N
Canonical SMILESCCC(C)C(C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CS)C(=O)
NC(CS)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)NC(C(C)CC)C(=O)NC(CS)C(=O)NC(CO)C(=
O)NC(CC(C)C)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=
O)NC(CCC(=O)O)C(=O)NC(CC(=O)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CS)C(=O)NC
(CC(=O)N)C(=O)O)NC(=O)CN.CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC(C)C)
C(=O)NC(C(C)C)C(=O)NC(CS)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=
O)NCC(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CC=C(C=C4)O)C
(=O)NC(C(C)O)C(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)O)C(=O)O)NC(=O)C(C)NC
(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC6=CN=CN6)NC(=O)C
(CO)NC(=O)CNC(=O)C(CS)NC(=O)C(CC(C)C)NC(=O)C(CC7=CN=CN7)NC(=O)C(CCC(=O)
N)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC8=CC=CC=C8)N    
Isomeric SMILESCC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]
(CCC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N
[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)
N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N
[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]
(CC2=CC=C(C=C2)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)CN.C
[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)
C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H]
(CC4=CC=CC=C4)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)
CNC(=O)[C@H](CS)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC5=CC=
C(C=C5)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@
H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC6=CN=CN6)NC(=O)[C@H](CO)NC(=O)
CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@H]
(CCC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC8=CC=CC=
C8)N)O
Therapeutic ClassHypoglycemic Agents
CAS NumberCAS 133107-64-9
FormulaC257H387N65O76S6
PubChem Compound IDCID 16132438.
SuperDrug ATC IDA10AB04
TargetInsulin receptorBinder[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Hope for insulin mimetic oral antidiabetic drugs. Eur J Endocrinol. 1999 Dec;141(6):561-2. To Reference



 

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