Therapeutic Targets Database
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TTD Drug ID: DAP000832

Drug Information
NameSertindole
SynonymsLu-23-174; 1-(2-(4-(5-Chloro-1-(p-fluorophenyl)indol-3-yl)piperidino)ethyl)-2-imidazolidinone; S-1991; L001396; DB06144; UNII-GVV4Z879SP; SerLect; 1-(2-(4-(5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl)-1-piperidinyl)ethyl)-2-imidazolidinone; CHEMBL12713; LS-79363; Sertindol; Sertindolum [INN-Latin]; 1-[2-[4-[5-Chloro-1-(p-fluorophenyl)indol-3-yl]piperidino]ethyl]-2-imidazolidinone; 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one; CHEBI:9122; 1-(2-(4-(5-Chloro-1-(4-fluorophenyl)-1H-indole-3-yl)-1-piperidinyl)ethyl)-2-imidazolidinone; Sertindole (USAN/INN); 2-Imidazolidinone, 1-(2-(4-(5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl)-1-piperidinyl)ethyl)-; 1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one; 2-Imidazolidinone, 1-(2-(4-(5-chloro-1-(4-fluorophenyl)-1H-indole-3-yl)-1-piperidinyl)ethyl)-; Serdolect; NCGC00181782-01; C07567; D00561; C066304; AC1L1SNB; AC1Q4NTT; SerLect (TN); SERTINDOLE; 106516-24-9; MolPort-005-933-379; Lu 23-174; PDSP2_001545; Sertindol [INN-Spanish]; PDSP1_001561; Sertindolum; C24H26ClFN4O; Sertindole [USAN:INN]; 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one; sertindole hydrochloride; CID60149
Trade NameSerdolect; Serlect
IndicationSchizophrenia
[ICD9: 295   ICD10: F20]
Approved    [1]
Structure

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InChI1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3
-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-
14H2,(H,27,31)
InChIKeyGZKLJWGUPQBVJQ-UHFFFAOYSA-N
Canonical SMILESC1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O    
Therapeutic ClassAntipsychotic Agents
CAS NumberCAS 106516-24-9
FormulaC24H26ClFN4O
PubChem Compound IDCID 60149.
PubChem Substance IDSID 9770.
ChEBI9122;
SuperDrug ATC IDN05AE03
SuperDrug CAS ID106516249;
TargetD(2) dopamine receptorAntagonist[2][3]
Ref 1The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31. To Reference
Ref 2Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved. Psychopharmacology (Berl). 2009 Jun 9. [Epub ahead of print] To Reference
Ref 3Dopamine D2(High) receptors moderately elevated by sertindole. Synapse. 2008 May;62(5):389-93. To Reference



 

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