Therapeutic Targets Database
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TTD Drug ID: DAP000842

Drug Information
NameAminoglutethimide
SynonymsAC1L1D0R; alpha-(p-Aminophenyl)-alpha-ethylglutarimide; HMS2090I05; Prestwick3_000244; Prestwick2_000244; Aminoglutetimida; A1947; Prestwick0_000244; Ba 16038; Cytadren (TN); NCGC00093615-02; KBio1_000884; NCGC00015110-02; KBioSS_000400; (+/-)-p-AMINOGLUTETHIMIDE; Novartis Brand of Aminoglutethimide; BSPBio_001832; HMS1920C09; Prestwick_243; dl-Aminoglutethimide; NCGC00093615-03; Spectrum5_000802; BRD-A25234499-001-05-0; AB00051935; CHEMBL488; STK802074; Spectrum4_000144; CPD000326785; SPBio_002247; Ba-16038; UNII-0O54ZQ14I9; BPBio1_000032; DB00357; CID2145; Aminoglutethimidum; AG-1; CPD-10532; Aminoglutethimide (USP/INN); EINECS 204-756-4; Aminoglutethimidum [INN-Latin]; SAM002589964; NSC330915; AC-12456; NCGC00093615-04; Spectrum3_000296; KBio2_000400; NINDS_000884; SPECTRUM1500115; Lopac0_000124; 2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl-; HMS2091I09; C 16038-BA; 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione; Aminoglutethimide [INN:BAN]; Glutarimide, 2-(p-aminophenyl)-2-ethyl-; DivK1c_000884; NCGC00093615-05; NCI60_002900; CCRIS 7562; Elipten; Aminoglutetimida [INN-Spanish]; 3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione; MolPort-001-828-287; D00574; aminoglutethimide; HMS1568B10; MLS000859924; KBio3_001332; SMP1_000017; Glutethimide, para-amino; BB_SC-1153; SPBio_000046; AKOS004120070; 3-Ethyl-3-(p-aminophenyl)-2,6-dioxopiperidine; A 9657; LS-72014; HSDB 7494; CHEBI:2654; KBioGR_000588; 3-(4-Aminophenyl)-3-ethyl-2,6-piperidindion; Spectrum2_000093; Prestwick1_000244; KBio2_002968; C07617; Cytadren; NCGC00015110-07; 2-(p-Aminophenyl)-2-ethylglutarimide; Spectrum_000040; SMR000326785; AC1Q2SPJ; MLS001213216; Ciba Vision Brand of Aminoglutethimide; HMS502M06; KBio2_005536; aminoglutethimide (AG); S1672_Selleck; IDI1_000884; ( inverted question mark)-p-Aminoglutethimide; (+-)-3-(p-Aminophenyl)-3-ethyl-2,6-piperidinedione; .alpha.-(p-Aminophenyl)-.alpha.-ethylglutarimide; BSPBio_000028; p-Aminoglutethimide; 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione; A9657_SIGMA; NCGC00093615-01; EU-0100124; D000616; Orimeten; BRN 0210656; (?)-p-Aminoglutethimide; VU0243029-3; 125-84-8
Trade NameCytadren
CompanyNorvatis Phamaceuticals Corporation
IndicationCushing's syndrome and metastatic breast cancer
[ICD9: 174, 175, 255.0   ICD10: C50, E24]
Approved    [1]
Cushing's syndrome and metastatic breast cancer
[ICD9: 174, 175, 255.0   ICD10: C50, E24]
Approved    [2]
Structure

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InChI1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-
6H,2,7-8,14H2,1H3,(H,15,16,17)
InChIKeyROBVIMPUHSLWNV-UHFFFAOYSA-N
Canonical SMILESCCC1(CCC(=O)NC1=O)C2=CC=C(C=C2)N    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 125-84-8
FormulaC13H16N2O2
PubChem Compound IDCID 2145.
PubChem Substance IDSID 9819.
SuperDrug ATC IDL02BG01
SuperDrug CAS ID000125848;
TargetAromataseInhibitor[3]
Cytochrome P450 11A1Inhibitor[1]
Ref 1Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma. Cell Immunol. 2000 Nov 25;206(1):7-15. To Reference
Ref 2Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 3Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol. 2007 Jul;20(7):1038-45. Epub 2007 Jun 30. To Reference



 

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