Therapeutic Targets Database
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TTD Drug ID: DAP000849

Drug Information
NameClofarabine
SynonymsDB00631; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine; clofarabinum; CID119182; Clolar (TN); 3S211048; Clofarabine; Bio-0121; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine; D03546; C1-F-Ara-A; LS-126466; Clofarabine (USAN/INN); CHEBI:681569; 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-; 2-Cl-2'-F-araA; 123318-82-1; S1218_Selleck; Clofarex; HMS2090A07; Clolar; FT-0082882; AC-274; AC1L3OC8; CFB; CAFdA; MolPort-005-941-711; Clolar, Evoltra, Clofarabine; Cl-F-Ara-A; ZINC03798247; Evoltra; DB07554; CHEMBL1750; Clofarabine [USAN]; 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine; UNII-762RDY0Y2H; 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine; AKOS005063562; clofarabina; (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Trade NameClolar; Evoltra
IndicationAcute lymphoblastic leukemia
[ICD9: 204.0   ICD10: C91.0]
Approved    [1]
Structure

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InChI1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3
(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
InChIKeyWDDPHFBMKLOVOX-AYQXTPAHSA-N
Canonical SMILESC1=NC2=C(N1C3C(C(C(O3)CO)O)F)N=C(N=C2N)Cl    
Isomeric SMILESC1=NC2=C(N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)N=C(N=C2N)Cl
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 123318-82-1
FormulaC10H11ClFN5O3
PubChem Compound IDCID 119182.
PubChem Substance IDSID 695844.
SuperDrug ATC IDL01BB06
L01BB06
TargetDNABinder[2]
DNAMultitarget[2]
Ribonucleoside-diphosphate reductaseInhibitor[2]
Ribonucleoside-diphosphate reductaseMultitarget[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30. To Reference



 

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