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TTD Drug ID: DAP000858

Drug Information
NameOrphenadrine
SynonymsEINECS 201-509-2; Mialgin (TN); Orfenadrina; 2-(Phenyl-o-tolylmethoxy)ethyldimethylamine; 83-98-7; Methyldiphenylhydramine; CHEBI:177779; DivK1c_000853; Orphenadrin; CID4601; KBio2_006661; 4682-36-4 (citrate); KBio2_001525; Lysantin; N,N-Dimethyl-2-(o-methyl-alpha-phenylbenzyl)oxy)ethylamine; Spectrum3_000531; KBioGR_000880; Orphenate; N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine; Myolin; CBDivE_006102; Orphenadrine (INN); Prestwick0_000239; KBio3_001641; SPBio_001255; Ethanamine, N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-; NINDS_000853; Spectrum4_000460; DB01173; orphenadrine; 2-Methyldiphenhydramine; Phenyl-o-tolylmethyl dimethyaminoethyl ether; C07935; 341-69-5 (hydrochloride); NCGC00089814-03; LS-68148; Spectrum5_001036; BPBio1_000349; BRN 1885151; CHEMBL900; Orfenadrina [INN-Spanish]; AC1L1IJ4; BSPBio_002141; Norflex Orphenadrine Citrate; Biorphen; Lopac0_000884; N,N-Dimethyl-2-[(o-methyl-alpha-phenylbenzyl)oxy]ethylamine; beta-Dimethylaminoethyl 2-methylbenzhydryl ether; WS 2434; Mefenamine; Ethylamine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-; beta-Dimethylaminoethyl-2-methylbenzhydryl ether; Orphenadine; Orphenadrinum; Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)-; MolPort-002-052-046; ORP; Orfro; ST50406606; Antiflex; KBio1_000853; AB00053510; Orphenadrine [INN:BAN]; Prestwick1_000239; NCGC00015771-09; Spectrum_001045; Mephenamine; CHEBI:7789; HSDB 3139; Mio-Rel; N,N-dimethyl-2-{[(2-methylphenyl)(phenyl)methyl]oxy}ethanamine; Brocasipal; Orphenadrinum [INN-Latin]; Orphenedrine; 4-06-00-04727 (Beilstein Handbook Reference); SPBio_002238; L001253; Sodium Mefenamine; N,N-dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamine; Prestwick2_000239; Spectrum2_001038; Orphenadinum; Oprea1_476547; o-Monomethyldiphenhydramine; BRD-A53576514-003-03-1; UNII-AL805O9OG9; o-Methyldiphenhydramine; Disipal; KBioSS_001525; BSPBio_000317; Brocadisipal; Prestwick3_000239; KBio2_004093; NCGC00089814-02; IDI1_000853; N,N-Dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamin; Myotrol; D08305; N,N-Dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine
Trade NameNorflex; Mephenamin; Disipal; Banflex; Flexon; Biorphen; Brocasipal
Company3M Pharmaceuticals
IndicationParkinson's disease
[ICD9: 332   ICD10: F02.3, G20]
Approved    [1]
Structure

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InChI1S/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-1
1-16/h4-12,18H,13-14H2,1-3H3
InChIKeyQVYRGXJJSLMXQH-UHFFFAOYSA-N
Canonical SMILESCC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C    
Therapeutic ClassAntiparkinson Agents
CAS NumberCAS 83-98-7
FormulaC18H23NO
PubChem Compound IDCID 4601.
PubChem Substance IDSID 10137.
SuperDrug ATC IDM03BC01
SuperDrug CAS ID000083987;
TargetGlutamate [NMDA] receptorAntagonist[2][3]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040249 To Reference
Ref 2Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine. Pain. 2009 Apr;142(3):225-35. Epub 2009 Feb 12. To Reference
Ref 3Dopamine/glutamate interactions in Parkinson's disease. Neurosci Biobehav Rev. 1997 Jul;21(4):393-400. To Reference



 

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