Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DAP000875

Drug Information
NameRanolazine
SynonymsNCGC00095177-03; RANOLAZINE; HMS2090L09; 95635-55-5; LS-187267; Ranexa; MLS002154149; RS-43285-003; BRD-A97674275-001-01-9; (-)-Ranolazine; SMR000857382; D05700; CHEMBL1404; NCGC00095177-02; MolPort-003-666-653; RS-43285; Ranolazine 2HCl; Ranexa, Ranolazine; CVT-303; HMS2093D21; BSPBio_002276; NCGC00015897-05; AC1Q5LYD; AC-1673; Ran4; I06-0160; RAN D; DB00243; AC1L1M17; HMS1922F16; Ranolazine dihydrochloride; 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-; Lopac0_001062; NCGC00095177-01; Ranexa (TN); 142387-99-3; N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide; Latixa; KEG-1295; CID56959; Ranolazine (USAN/INN); UNII-A6IEZ5M406; 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-; SPECTRUM1505366; S1799_Selleck; ( -)-Ranolazine; I01-2008
Trade NameRanexa
CompanyCV Therapeutics
IndicationChronic angina
[ICD9: 413   ICD10: I20]
Approved    [1]
Structure

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InChI1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-1
4-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1
-3H3,(H,25,29)
InChIKeyXKLMZUWKNUAPSZ-UHFFFAOYSA-N
Canonical SMILESCC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O    
Therapeutic ClassAnalgesics
CAS NumberCAS 142387-99-3
FormulaC24H33N3O4
PubChem Compound IDCID 56959.
PubChem Substance IDSID 194150.
SuperDrug ATC IDC01EB18
C01EB18
TargetVoltage-gated sodium channel subunit alpha Nav1.7Blocker[2]
Voltage-gated sodium channel subunit alpha Nav1.7Multitarget[2]
Voltage-gated sodium channel subunit alpha Nav1.8Blocker[2]
Voltage-gated sodium channel subunit alpha Nav1.8Multitarget[2]
Ref 1Emerging drugs for acute and chronic heart failure: current and future developments. Expert Opin Emerg Drugs. 2007 Mar;12(1):75-95. To Reference
Ref 2Block of tetrodotoxin-sensitive, Na(V)1.7 and tetrodotoxin-resistant, Na(V)1.8, Na+ channels by ranolazine. Channels (Austin). 2008 Nov-Dec;2(6):449-60. Epub 2008 Nov 7. To Reference



 

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