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TTD Drug ID: DAP000894

Drug Information
NameDemecarium bromide
SynonymsBenzenaminium, 3,3'-(1,10-decanediylbis((methylimino)carbonyloxy))bis(N,N,N-trimethyl-, dibromide; AR-1I3519; (m-Hydroxyphenyl)trimethylammonium bromide decamethylenebis(methylcarbamate); Frumtosnil; Decamethylenebis(N-methylcarbamic acid m-dimethylaminophenyl ester) bromomethylate; LS-18445; Demecarium bromide [INN:BAN]; D00667; demecastigmine; Bromure de demecarium [INN-French]; 56-94-0; HSDB 2168; CHEBI:4391; N,N'-Bis(3-trimethylammoniumphenoxycarbonyl)-N,N'-dimethyldecamethylenediamine dibromide; BC 48; Demecarium; Ammonium, (m-hydroxyphenyl)trimethyl-, bromide, decamethylenebis(methylcarbamate) (2:1); Humorsol (TN); Bromuro de demecario; CHEMBL1200514; Bromuro de demecario [INN-Spanish]; DEMECARIUM BROMIDE; (m-Hydroxyphenyl)trimethylammonium bromide decamethylenebis(methylcarbamate) (2:1); 3,3'-{decane-1,10-diylbis[(methylcarbamoyl)oxy]}bis(N,N,N-trimethylanilinium) dibromide; C21H36N2O2.C12H18N2O2; trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylazaniumyl)phenoxy]carbonylamino]decyl]carbamoyl]oxyphenyl]azanium dibromide; AC1L1LIL; Demecarii bromidum; UNII-61D5V4OKTP; Ammonium, (m-hydroxyphenyl)trimethyl-, bromide, decamethylenebis(methylcarbamate); Visumatic; Tosmicil; decamethylenebis(m-dimethylaminophenyl-N-methylcarbamate)dimethobromide; Bromure de demecarium; Demecarii bromidum [INN-Latin]; Tosmilene; CID5965; Demekastigmine bromide; decamethylenebis[m-dimethylaminophenyl n-methylcarbamate] dimethobromide; Humorsol; (m-Hydroxyphenyl)trimethylammonium bromide decamethylenebis(methylcarbamate) (7CI); Demekarium bromide; EINECS 200-301-9; I06-2187; Tonilen; MolPort-005-943-446; AC1Q1R6E; Demecarium bromide (USP/INN); Tosmilen; AC-305; Visumiotic; Decamethylenebis(m-dimethylaminophenyl-N-methylcarbamate) dimethobromide; DB00944
IndicationOpen-angle glaucoma
[ICD9: 365   ICD10: H40-H42]
Approved    [1]
Structure

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InChI1S/C32H52N4O4.2BrH/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)2
3-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36
(6,7)8;;/h17-22,25-26H,9-16,23-24H2,1-8H3;2*1H/q+2;;/p-2
InChIKeyYHKBUDZECQDYBR-UHFFFAOYSA-L
Canonical SMILESCN(CCCCCCCCCCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C)C(=O)OC2=CC=CC(=C2)[N+]
(C)(C)C.[Br-].[Br-]    
Therapeutic ClassParasympathomimetics
CAS NumberCAS 56-94-0
FormulaC32H52Br2N4O4
PubChem Compound IDCID 5965.
PubChem Substance IDSID 148800.
SuperDrug ATC IDS01EB04
SuperDrug CAS ID000056940;
TargetAcetylcholinesteraseInhibitor[2][3]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011860 To Reference
Ref 2The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. Vet Ophthalmol. 2003 Mar;6(1):23-5. To Reference
Ref 3Neuromuscular blocking agents and axial teratogenesis in the avian embryo. Can axial morphogenetic disorders by explained by pharmacological action upon muscle tissue? Teratology. 1981 Apr;23(2):259-71. To Reference



 

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