Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DAP000902

Drug Information
NameNicergoline
SynonymsBPBio1_000280; HMS2092F07; Spectrum2_001414; Nicergoline [USAN:BAN:INN:JAN]; KBio3_002787; QTL1_000060; Nargoline; Nicergolinum; HMS1568M16; Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester); NSC 150531; HMS1923O09; BSPBio_000254; Nimergoline base; KBioSS_001850; RP 19651; 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate (ester); LS-64447; Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI); BSPBio_003533; Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-; Sermion (TN); AC1L1QT0; HMS2089I03; Spectrum_001370; Spectrum3_001933; N7889_FLUKA; 8-beta-((5-Bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline; CID34040; 5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester; 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat); Nicergolina; 27848-84-6; Prestwick1_000147; I06-1875; BRD-K76810206-001-05-7; Nicergoline (JP15/USAN/INN); Nicergolin; AKOS005067888; Spectrum5_001352; SPBio_002193; Prestwick0_000147; D01290; HMS500G06; EINECS 248-694-6; Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester); 1-Methyl-lumilysergol 8-(5-bromonicotinate) 10-methyl ether; KBio2_004418; 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat) [German]; NCGC00024678-02; 10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyrindinecarboxylate (ester); Nimergoline; Nicergolin [German]; N7889_SIGMA; Nicotergoline; Nicergolina [DCIT]; IDI1_000124; SPBio_001488; Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester); nicergoline; C24H26BrN3O3; Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8beta)-, 5-bromo-3-pyridinecarboxylate (ester); Prestwick3_000147; KBio1_000124; BRN 4828393; Nicergolinum [INN-Latin]; (+)-10-Methoxy-1,6-dimethylergoline-8-beta-methanol 5-bromonicotinate; F.I. 6714; Prestwick2_000147; DivK1c_000124; Bio-0069; 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate; Spectrum4_000440; KBio2_006986; DB00699; KBio2_001850; MolPort-002-513-778; Sermion; MNE; NINDS_000124; KBioGR_000800; FI 6714; SPECTRUM1501133; NCGC00024678-03
Trade NameSermion
IndicationSenile dementia
[ICD9: 290-294   ICD10: F01-F07]
Approved    [1]
Structure

Click to save drug structure in 3D MOL format

Click to save drug structure in 2D MOL format
InChI1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)
9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,
15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
InChIKeyYSEXMKHXIOCEJA-FVFQAYNVSA-N
Canonical SMILESCN1CC(CC2(C1CC3=CN(C4=CC=CC2=C34)C)OC)COC(=O)C5=CC(=CN=C5)Br    
Isomeric SMILESCN1C[C@@H](C[C@]2([C@H]1CC3=CN(C4=CC=CC2=C34)C)OC)COC(=O)C5=CC(=CN=C5)Br
Therapeutic ClassVasodilator Agents
CAS NumberCAS 27848-84-6
FormulaC24H26BrN3O3
PubChem Compound IDCID 34040.
PubChem Substance IDSID 175827.
SuperDrug ATC IDC04AE02
SuperDrug CAS ID027848846;
TargetAlpha2-adrenergic receptorAntagonist[2][3]
Ref 1Drug information of Nicergoline, 2008 To Reference
Ref 2Effect of non-selective alpha-adrenergic receptor antagonist nicergoline on the activity of neurons in the ventral lateral thalamic nucleus. Fiziol Zh. 2005;51(4):29-35. To Reference
Ref 3Nicergoline in senile dementia of Alzheimer type and multi-infarct dementia: a double-blind, placebo-controlled, clinical and EEG/ERP mapping study. Psychopharmacology (Berl). 1995 Feb;117(4):385-95. To Reference



 

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.


Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543